Diagnoses Associated With Persistent Elevation of Creatine Kinase
Study Details
Study Description
Brief Summary
Serum creatinine kinase (CK) level varies with age, gender, race and physical activity. For these reasons there is no normal serum CK level. Many pathological situations cause hyperCKemia, such as neuromuscular disorders (muscular dystrophy, inflammatory myositis, mitochondrial myopathy) and multiple systemic causes. The diagnostic approach to pauci or asymtomatic hyperCKemia can therefore be difficult and lead to multiple, and sometimes invasive tests, such as muscle biopsy. This study aims to describe the diagnoses associated with persistent elevation of serum creatine kinase and to precise the role of the muscule biopsy.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Patients with elevated creatine kinase
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Other: no intervention
retrospective descriptive without intervention
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Outcome Measures
Primary Outcome Measures
- Diagnosis [at the end of all investigations, an average of 12 months]
The final diagnosis, as written in the medical record at the end of the investigations in the ward of internal medicin, responsible for the elevation of creatine kinase between: inflammatory myositis, mitochondrial myopathy, muscular dystrophy, non neuromuscular pathology
Secondary Outcome Measures
- Muscle biopsy [at the end of all investigations, an average of 12 months]
Among the patients who underwent a muscle biopsy, number of anormal biopsies that contributed to make the final diagnosis responsible of the elevation of creatine kinase
- Clinical presentation [at the end of all investigations, an average of 12 months]
association between the initial clinical presentation and the final diagnosis
- Paraclinical presentation [at the end of all investigations, an average of 12 months]
association between the initial paraclinical presentation and the final diagnosis
Eligibility Criteria
Criteria
Inclusion Criteria:
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patients hospitalised in a ward of internal medicin
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having a persistent elevation of serum creatine kinase >3 times the upper normal laboratory value, repeated for 2 times
Exclusion Criteria:
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known neuro-muscular disease causing elevation of creatine kinase
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evident post-traumatic cause responsible for the elevation of creatine kinase
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incomplete medical records
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | CHRU Nancy | Nancy | France | 54000 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021PI034