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Diagnosis of Ascites in Infants and Children

Sponsor
Assiut University (Other)
Overall Status
Unknown status
CT.gov ID
NCT03341221
Collaborator
(none)
50
Enrollment
11
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Ascites is the pathologic accumulation of fluid within the peritoneal cavity. Causes of ascites in infants and children :hepatobiliary disorders,serositis, neoplasm, cardiac, genitourinary disorder, metabolic disease and others.

Diagnosis of ascites :history of abdominal distention, increasing weight, respiratory embarrassement, symptoms and signs of (hepatic ,cardiac,renal disease, tuberculosis and malignancy).

lnvestigation:complete blood count, complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test, chest and abdominal plain films,abdominal ultrasound, upper gastrointestinal endoscopy, abdominal paracentesis for ascitic fluid analysis .

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity .

    causes of ascites in infants and children :

    • Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation)

    • Serositis (crohn's disease, eosinophilic enteropathy , Henoch- Shonlein purpura )

    • Neoplasm (lymphoma, wilm's tumor ,Glioma, Germ cell tumor, Ovarian tumor,mesothelioma, Neroblastoma )

    • Cardiac (Heart failure )

    • Metabolic disease

    • Gastrointestinal disorder (Nephrotic syndrome, peritoneal dialysis ). Diagnosis of ascites :History of abdominal distention, increasing weight, respiratory embarrassement, jaundice, bleeding (haematemsis, melena, and epistaxis ),Pruritus ,Growth failure ,abdominal pain, fever,Cyanosis, ,dyspnea during suckling, Orthopnea, Buffy eyes, lower limb swelling, Haematrruria .

    By examination : Tachycardia ,Tachypnea ,Hypertension ,cyanosis, jaundice, clubbing of fingers ,limb edema ,Hepatomegaly, splenomegaly, dilated abdominal wall veins.

    Investigations :

    Laboratory tests :complete blood count , complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test.

    Imaging studies :chest and abdominal plain films, abdominal ultrasound, upper gastrointestinal endoscopy CT, MR I, Abdominal paracentesis for ascitic fluid analysis :cell count / cytology ,Gram 'stain and culture, Total proteins (albumin /globulin ratio ), Glucose, Amylase, lactase dehydrogenase, Triglycerides,Bilirubin.

    Serum ascites albumin gradient (SAAG )is the best single test for classification of ascites into portal hypertensive (SAAG >1.1g/dl) and non-portal hypertensive (SAAG <1.1g/dl) causes.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    50 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Cross-Sectional
    Official Title:
    Diagnosis of Ascites in Infants and Children
    Anticipated Study Start Date :
    Dec 1, 2017
    Anticipated Primary Completion Date :
    Nov 1, 2018
    Anticipated Study Completion Date :
    Nov 1, 2018

    Arms and Interventions

    Arm Intervention/Treatment
    One group

    Diagnosis of ascites in infants and children by history, examination and investigations

    Outcome Measures

    Primary Outcome Measures

    1. Diagnosis of ascites in infants and children with hepatic, cardiac, renal disease, tuberculosis and malignancy [1 year]

      Diagnosis of ascites in infants and children fromega age of 1month to 18 year

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    1 Month to 18 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • age from 1month to 18 year

    • infants and children with ascites (hepatic, cardiac, renal, malignant or tuberculous )

    • infants and children with peritonitis

    Exclusion Criteria:

    • age <1month

    • surgical conditions as ruptured viscous or located abscess

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Assiut University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Asmaa abo bakr Ahmed, Doctor, Assiut University
    ClinicalTrials.gov Identifier:
    NCT03341221
    Other Study ID Numbers:
    • Assuit university 246810
    First Posted:
    Nov 14, 2017
    Last Update Posted:
    Nov 14, 2017
    Last Verified:
    Oct 1, 2017
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Ascites

    Study Results

    No Results Posted as of Nov 14, 2017