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Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

Sponsor
Li Haiyan (Other)
Overall Status
Unknown status
CT.gov ID
NCT01665729
Collaborator
(none)
1,000
Enrollment
1
Location
54
Duration (Months)
18.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important.

The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    1000 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
    Study Start Date :
    Jun 1, 2011
    Actual Primary Completion Date :
    Aug 1, 2012
    Anticipated Study Completion Date :
    Dec 1, 2015

    Arms and Interventions

    Arm Intervention/Treatment
    artery-artery embolus

    There is no hypoperfusion ( contralateral compensatory is good )
    Hypoperfusion

    Contralateral compensatory not sufficient
    Hypoperfusion and embolus amotic

    Hypoperfusion and embolus amotic

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years to 79 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      one of two conditions:

      1. conscious patients with any of NIHSS score = 1,or

      2. NIHSS ≤ 3

      Exclusion Criteria:

      • patients Over 80 years of age

      • patients With serious heart, lung, liver, kidney dysfunction or

      • severe systemic complications,

      • a known tumor,

      • pregnancy,

      • having a history of cerebral hemorrhage

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University Guangzhou Guangdong China 510630

      Sponsors and Collaborators

      • Li Haiyan

      Investigators

      • Study Chair: Zhengqi Lu, prof., Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Li Haiyan, Dr., Third Affiliated Hospital, Sun Yat-Sen University
      ClinicalTrials.gov Identifier:
      NCT01665729
      Other Study ID Numbers:
      • 2011-2-48
      First Posted:
      Aug 15, 2012
      Last Update Posted:
      Aug 15, 2012
      Last Verified:
      Aug 1, 2012
      Keywords provided by Li Haiyan, Dr., Third Affiliated Hospital, Sun Yat-Sen University
      etiology
      pathogenesis
      minor ischaemic stroke
      types
      intervention
      Additional relevant MeSH terms:
      Stroke
      Ischemic Stroke
      Cerebral Infarction
      Ischemia

      Study Results

      No Results Posted as of Aug 15, 2012