Diagnostic Accuracy of the Vegetative and Minimally Conscious State
Study Details
Study Description
Brief Summary
The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
In this study, DOC patients with clinical consensus of DOC were enrolled. The investigators used Coma Recovery Scale-revision (CRS-R) to assess consciousness levels for all DOC patients during ten days.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients with disorders of consciousness
|
Diagnostic Test: Coma Recovery Scale-revision
Patients were assessed by Coma Recovery Scale-revision to detect the DOC patients enrolled by clinicians.
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Outcome Measures
Primary Outcome Measures
- Assessed by the Coma Recovery Scale-Revised [Within 10 days]
All patients were assessed by the Coma Recovery Scale-Revised within 10 days to detect the consciousness level. CRS-R consists of six sub-scales with 23 items, which evaluate the patients' auditory, visual, motor, Oromotor/Verbal, communication and arousal functions. For each subscale, the lower score reflected reflexivity related to the brain stem, while the higher score reflected non-reflexivity related to higher cortical functions (0-23).
Eligibility Criteria
Criteria
Inclusion
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at least 18 years old;
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acquired brain injury;
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no neuromuscular blockers or sedatives were used within 48 hours of enrollment.
Exclusion Criteria:
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there are functional disorders caused by progressive mental diseases;
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persistent seizures;
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unstable vital signs;
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double upper limb frustration, fracture.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | International Vegetative State and Consciousness Science Institute, Hangzhou Normal University | Hangzhou | Zhejiang | China | 3100036 |
Sponsors and Collaborators
- Hangzhou Normal University
Investigators
- Study Chair: Haibo Di, Pro., Hangzhou Normal University
Study Documents (Full-Text)
None provided.More Information
Publications
- Farquhar I, Fairclough JA. Sciatic block in lower limb surgery. Injury. 1990 Mar;21(2):107-9.
- Stender J, Gosseries O, Bruno MA, Charland-Verville V, Vanhaudenhuyse A, Demertzi A, Chatelle C, Thonnard M, Thibaut A, Heine L, Soddu A, Boly M, Schnakers C, Gjedde A, Laureys S. Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study. Lancet. 2014 Aug 9;384(9942):514-22. doi: 10.1016/S0140-6736(14)60042-8. Epub 2014 Apr 15.
- van Erp WS, Lavrijsen JC, Vos PE, Bor H, Laureys S, Koopmans RT. The vegetative state: prevalence, misdiagnosis, and treatment limitations. J Am Med Dir Assoc. 2015 Jan;16(1):85.e9-85.e14. doi: 10.1016/j.jamda.2014.10.014. Erratum in: J Am Med Dir Assoc. 2019 May;20(5):652.
- 2018N56745