Comparing the Diagnostic Role of PET/MRI and of PET/CT Among Patients With Gastric Cancer
Study Details
Study Description
Brief Summary
The results of PET/MRI and PET/CT in each recruited gastric cancer patients will be compared.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
A prospective comparison of PET/MRI and PET/CT for gastric cancer will be performed,to evaluate the value of PET/MRI in predicting the preoperative staging and resectability of gastric cancer and investigate the role of PET/MRI in gastric cancer diagnosis.The evaluation parameters are the diagnostic accuracy of gastric cancer staging( including the overall accuracy, sensitivity, and specificity) and the receiver operating characteristic (ROC).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Gastric cancer Each patient will perform a PET/MRI examination,and in the next day,a PET/CT.All the examinations are performed before the operation. |
Device: PET/MRI
The recruited patients will receive a PET/MRI examination to evaluation the stage and resectability of the cancer.
Other Names:
Device: PET/CT
At the next day of PET/MRI examination,A PET/CT examination will be performed.
Other Names:
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Outcome Measures
Primary Outcome Measures
- The results of the PET/MRI and PET/CT examination [3 days]
Two experienced radiologists independently assess the TNM staging of gastric cancer using preoperative PET/MRI and PET/CT images
Secondary Outcome Measures
- Histopathological diagnosis [5 days]
including definitely T stage in Tx, number of regional lymph node metastasis,result of histologic subtypes of carcinoma,result of other cytological examination.
- Results of CT/Endoscopic ultrasound(EUS) image [3 days]
Experienced radiologists assess definitely T stage in Tx, number of regional lymph node metastasis,with or without distant metastasis.
- Numerical values of Standard uptake value(SUV) [3 days]
Standard uptake value(SUV) is defined as the ratio of the image derived radioactivity concentration and the whole body concentration of the injected radioactivity.
- Apparent Diffusion Coefficient(ADC) [3 days]
Apparent Diffusion Coefficient(ADC) will be measured using a curved Placement of region of interest(ROI) to include the high signal and be read out on ADC maps by Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) analysis software.
- The expression level of Receptor tyrosine-protein kinase erbB-2(HER2) [5 days]
Acquire from pathology results
- The expression level of Receptors for vascular endothelial growth factor(VEGFR) [5 days]
Acquire from pathology results
- Follow-up data [at lest 6 months]
results of conventional imaging examination and tumor biomarkers examination.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Histological diagnosis of gastric cancer
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No previous treatment history for gastric cancer
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Without complications of obstruction,bleeding and so on
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Without severe diabetes,the levels of blood glucose <6.2 mmol/L .
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No cardiac pacemarker,never stimulator or other metal substitute materials in vivo.
Exclusion Criteria:
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With other neoplastic disease.
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Suffering acute inflammatory disease
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History of chemo-radiotherapy
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Suffering prostate hyperplasia,glaucoma
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Chinese PLA General Hospital
Investigators
- Study Director: Jianxin Cui, Doctor, the Chinese PLA General Hospital
- Principal Investigator: Yi Liu, the Chinese PLA General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Experiment20160901