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Diagnostic Usefulness of Fluorine-18-α-Methyltyrosine PET in Combination With 18F-FDG in Sarcoidosis Patient

Sponsor
Gunma University (Other)
Overall Status
Completed
CT.gov ID
NCT00369980
Collaborator
(none)
1
Location
83
Duration (Months)

Study Details

Study Description

Brief Summary

L-[3-18F]-α-methyltyrosine (FMT) is amino-acid tracer for positron emission tomography (PET), and is used for tumor detection because malignant tumor cells accumulate 18F-FMT based on the increased expression of amino-acid transporter. This study was conducted to investigate a usefulness of 18F-FMT PET in combination with 18F-FDG PET for the diagnosis of sarcoidosis in patients with suspected malignancy.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Prospective
    Study Start Date :
    Sep 1, 1998
    Study Completion Date :
    Aug 1, 2005

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • Eligible patients were required to have histologically proven noncaseating epithelioid cell granuloma and at least one disease that the possibility of coexistent malignancy could not be excluded as follows; 1) extrapulmonary lesions mimicking malignant diseases including systemic lymphadenopathy, hepatosplenic involvement, or other lesions, 2) multiple nodular lesions mimicking pulmonary metastasis, 3) the occurrence of BHL in cancer patient.
      Exclusion Criteria:
      • The patients that PET imaging using 18F-FDG and 18F-FMT was performed before establishment of the final diagnosis of sarcoidosis, patients undergoing treatment for sarcoidosis before the PET study, and patient having diabetes mellitus.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Gunma University Graduate School of Medicine Gunma Japan 371-8511

      Sponsors and Collaborators

      • Gunma University

      Investigators

      • Principal Investigator: kyoichi kaira, MD, Gunma University Graduate School of Medicine

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00369980
      Other Study ID Numbers:
      • GunmaU
      First Posted:
      Aug 30, 2006
      Last Update Posted:
      Nov 7, 2006
      Last Verified:
      Aug 1, 2005
      Additional relevant MeSH terms:
      Sarcoidosis

      Study Results

      No Results Posted as of Nov 7, 2006