Dichloroacetate Kinetics, Metabolism and Toxicology
Sponsor
National Institute of Environmental Health Sciences (NIEHS) (NIH)
Overall Status
Completed
CT.gov ID
NCT00015015
Collaborator
(none)
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Study Details
Study Description
Brief Summary
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
Study Design
Study Type:
Observational
Observational Model:
Defined Population
Time Perspective:
Prospective
Study Start Date
:
Dec 1, 1994
Study Completion Date
:
Oct 1, 2002
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
3 Months
to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Children with congenital lactic acidosis Healthy adult volunteers
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Univ. of Florida | Gainesville | Florida | United States | 32610 |
Sponsors and Collaborators
- National Institute of Environmental Health Sciences (NIEHS)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00015015
Other Study ID Numbers:
- 7355-CP-001
First Posted:
Apr 19, 2001
Last Update Posted:
Sep 4, 2006
Last Verified:
Sep 1, 2006
Keywords provided by ,
,
Additional relevant MeSH terms: