Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort

Sponsor

Karolinska Institutet (Other)

Overall Status

Completed

CT.gov ID

NCT03350568

Collaborator

(none)

43,880

Enrollment

Location

159

Actual Duration (Months)

276

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures interactions between antioxidants in the whole diet, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Condition or Disease	Intervention/Treatment	Phase
Myocardial Infarction Diet Osteoarthritis	Other: Total dietary NEAC assessed at baseline

Detailed Description

Aim: Among an initial sample of 43,880 men and women who participated in the Swedish National March Cohort in 1997 the investigators aimed to investigate the effect of dietary Non Enzymatic Antioxidant Capacity (NEAC), assessed by a validated food frequency questionnaire at baseline, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Identification of cases: Incident cases of myocardial infarction (ICD-10 code I21) and osteoarthritis (ICD-10 M15-19) were identified through exact linkages to the Swedish registries of population, migration, death, cancer, and inpatient care, using the national registration numbers as identifiers.

Main methods: The investigators fitted Cox proportional hazards regression models with age as underlying time scale to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for each outcome of interest at different levels of dietary NEAC. The investigators fitted multiple imputation models based on chained equations to address missingness of confounder variables.

Study Design

Study Type:

Observational

Actual Enrollment :

43880 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Study 1: Dietary Non Enzymatic Antioxidant Capacity and the Risk of Myocardial Infarction - The Swedish National March Cohort; Study 2: Dietary Total Antioxidant Capacity and Risk of Osteoarthritis in the Swedish National March Cohort

Actual Study Start Date :

Oct 1, 1997

Actual Primary Completion Date :

Dec 31, 2010

Actual Study Completion Date :

Dec 31, 2010

Outcome Measures

Primary Outcome Measures

Myocardial Infarction [October 1, 1997-December 31, 2010]
Based on ICD-10 I21
Osteoarthritis [October 1, 1997-December 31, 2010]
Based on ICD-10 M15-19

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Exclusion Criteria Study 1:

Incorrect national registration number
Subjects who were <18 years
Emigration before beginning of follow-up
Death before beginning of follow-up
Cancer diagnosis
Any cardiovascular disease
Extreme energy intake

Exclusion Criteria Study 2:

Incorrect national registration number
Subjects who were <40 years
Emigration before beginning of follow-up
Death before beginning of follow-up
Osteoarthritis diagnosis
Bone cancer- or metastases
Joint injury or any arthropathy disease other than osteoarthritis
Extreme energy intake

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Karolinska Institutet	Stockholm		Sweden

Sponsors and Collaborators

Karolinska Institutet

Investigators

Principal Investigator: Ylva Trolle Lagerros, MD, PhD, Department of Medicine, Clinical Epidemiology, Karolinska Institutet; Department of Medicine, Clinic of Endocrinology, Karolinska University Hospital