CIRCAF_WOM: Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women

• Sponsor: Universidad Francisco de Vitoria (Other)
• Overall Status: Completed
• CT.gov ID: NCT05880186
• Collaborator: Universidad de Granada (Other), Universidad Rey Juan Carlos (Other), Camilo Jose Cela University (Other)
• Enrollment: 14
• Location: 1
• Arms: 2
• Actual Duration (Months): 1.9
• Patients Per Site Per Month: 7.2

Study Details

Study Description

Brief Summary

Caffeine is a natural stimulant with well-recognized metabolic benefits, however, there is a lack of studies investigating the time-of-day caffeine influence to enhance fat oxidation in women. The aim of this study was to evaluate the influence of the time of the day on the effect of caffeine on maximal rate of fat oxidation during aerobic exercise in women.

Condition or Disease	Intervention/Treatment	Phase
Dietary Supplement	Dietary Supplement: Acute caffeine supplementation	N/A

Detailed Description

Caffeine is a natural stimulant with well-recognized sports performance benefits. Aside its performance-enhancing effect, caffeine has the potential of increasing fat utilization during aerobic exercise at submaximal intensities, lowering-down the contribution of carbohydrate as a fuel. This property of caffeine may provoke a glycogen-sparing effect in the skeletal muscle and liver for exercise situations where carbohydrate availability may be a challenge. Additionally, the capacity of caffeine to enhance fat utilization during exercise could be of interest for improving health outcomes as it may increase the rate of change in body composition in exercise programs. Maximal fat oxidation rate (MFO) during exercise is a remarkable physiological indicator associated with metabolic flexibility/body weight loss and endurance performance To date, it is unknown if caffeine increases MFO in the same proportion during morning and evening exercise trials in women. For this reason, the aim of the present study was to evaluate the influence of the time of the day on the effect of caffeine on MFO in women. We hypothesised that caffeine would increase MFO during morning and evening exercise and this effect would be of similar magnitude at both times of day.

Study Design

• Study Type: Interventional
• Actual Enrollment: 14 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Intervention Model Description: Dietary Supplement: caffeine acute supplementationDietary Supplement: caffeine acute supplementation
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Treatment
• Official Title: Influence of the Time of Day in the Effect of Caffeine on Maximal Fat Oxidation During Exercise in Women. A Randomized, Crossover, Double-blind, and Placebo-controlled Study
• Actual Study Start Date: Feb 9, 2021
• Actual Primary Completion Date: Apr 9, 2021
• Actual Study Completion Date: Apr 9, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Caffeine intake Test in the morning A dose of 3 mg/kg of caffeine (Bulk Powders, Essex, United Kingdom) was ingested before the beginning of each test. Test in the evening A dose of 3 mg/kg of caffeine (Bulk Powders, Essex, United Kingdom) was ingested before the beginning of each test.	Dietary Supplement: Acute caffeine supplementation; To evaluate the influence of the time of the day (i.e., morning vs evening) on the effect of caffeine on maximal fat oxidation in women.
Placebo Comparator: Placebo intake Test in the morning A dose of 3 mg/kg of placebo (Cellulose, Guinama, Valencia, Spain) was ingested before the beginning of each test. Test in the evening A dose of 3 mg/kg of placebo (Cellulose, Guinama, Valencia, Spain) was ingested before the beginning of each test	Dietary Supplement: Acute caffeine supplementation; To evaluate the influence of the time of the day (i.e., morning vs evening) on the effect of caffeine on maximal fat oxidation in women.

Outcome Measures

Primary Outcome Measures

1. MFO [2-months]

   Maximal fat oxidation during exercise

Secondary Outcome Measures

1. FATmax [2-months]

   The intensity of exercise that elicits MFO

2. RPE [2-months]

   Rate of percevied exertion during exercise

3. FAT AND CHO oxidation [2-months]

   Fat and carbohydrates oxidation

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• To be non-smokers.

• To have low caffeine intake (i.e., < 50 mg of caffeine per day in the previous 2 months)

• To show no previous history of cardiopulmonary diseases or having suffered musculoskeletal injuries in the previous 6 months.

• To have a regular duration of their menstrual cycle for the previous 6 months.

• To confirm no existence of any type of menstrual disorders such as dysmenorrhea, amenorrhea, or strong symptoms associated with pre-menstrual syndrome.

Exclusion Criteria:

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Universidad Francisco de Vitoria	Pozuelo De Alarcón	Madrid	Spain	28223

Sponsors and Collaborators

• Universidad Francisco de Vitoria
• Universidad de Granada
• Universidad Rey Juan Carlos
• Camilo Jose Cela University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Universidad Francisco de Vitoria
• ClinicalTrials.gov Identifier: NCT05880186
• Other Study ID Numbers: UFVitoria_2
• First Posted: May 30, 2023
• Last Update Posted: May 30, 2023
• Last Verified: May 1, 2023

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Caffeine

Study Results

No Results Posted as of May 30, 2023