Caffeine and Sodium Citrate Ingestion

Sponsor

Swiss Paraplegic Centre Nottwil (Other)

Overall Status

Completed

CT.gov ID

NCT01591226

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.

The aim of the study is to investigate whether caffeine or sodium citrate ingestion could enhance performance in spinal cord injured wheelchair athletes. It is a double blind, placebo controlled and randomized study.

Condition or Disease	Intervention/Treatment	Phase
Dietary Supplements Heart Rate/Drug Effects Lactic Acid/Metabolism Physical Education and Training/Methods Wheelchairs	Dietary Supplement: Caffeine Dietary Supplement: Sodium Citrate Dietary Supplement: Mannitol Dietary Supplement: Sodium Chloride	N/A

Detailed Description

The athletes have to complete four 1500m tests on a training roller. Before each treatment they get different supplementations. Once they get sodium citrate and a placebo, once caffeine and a placebo, once sodium citrate and caffeine and for the fourth treatment they get twice a placebo. Two hours after starting with the supplementation they have to complete the 1500m as fast as possible. Time to complete 1500m, blood pH, plasma bicarbonate, sodium concentration, heart rate, oxygen consumption, blood lactate concentration and rate of perceived exertion (RPE) were measured.

Study Design

Study Type:

Interventional

Actual Enrollment :

9 participants

Allocation:

Randomized

Intervention Model:

Factorial Assignment

Masking:

Triple (Participant, Care Provider, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

Effects of Caffeine and Sodium Citrate Ingestion in 1500m Wheelchair Racing Athletes

Study Start Date :

Feb 1, 2012

Actual Primary Completion Date :

Sep 1, 2012

Actual Study Completion Date :

Sep 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Caffeine 6mg per kg bodyweight ingested 60min before test	Dietary Supplement: Caffeine gelatine capsule 6mg/kg bodyweight 60min prior test Dietary Supplement: Sodium Chloride sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test
Placebo Comparator: Placebo Sodium chloride and mannitol as placebo are ingested by the athlete	Dietary Supplement: Mannitol gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test Dietary Supplement: Sodium Chloride sodium chloride diluted in 7dl water 0.045g/kg bodyweight 120-90min prior test
Active Comparator: Sodium Citrate sodium citrate diluted in 7dl water, ingestion 120 to 90min prior test	Dietary Supplement: Sodium Citrate 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test Dietary Supplement: Mannitol gelatine capsule filled with mannitol (100mg per capsule) ingested 60min prior test
Active Comparator: Caffeine and Sodium Citrate sodium citrate 120-90min prior test capsules:60min prior test	Dietary Supplement: Caffeine gelatine capsule 6mg/kg bodyweight 60min prior test Dietary Supplement: Sodium Citrate 0.5g/kg bodyweight diluted in 7dl water ingested 120-90min prior test

Outcome Measures

Primary Outcome Measures

Time [3 weeks]
Time to complete 1500m

Secondary Outcome Measures

Heart Rate [during study phase of 3 week (4 tests)]
Heart Rate measured from 2min before the test until 5min after the 1500m-test.
Lactate Concentration [during the 3 weeks study phase]
1min before starting the warm up, 15s after the end of the warm up, 15s after completing the test, 2min/4min/6min/8min/10min after the test
blood pH, sodium concentration and plasma bicarbonate [during the 3 weeks of study phase]
1min before starting with the ingestion of the fluid, immediately before starting the warm up, just immediately before starting the 1500m test.
Oxygen Consumption [during 3 weeks of study phase]
oxygen consumption (VO2(ml/min/kg), VCO2(ml/min), RER (VCO2/VO2)) starting of the measurement is 2min before the start of the 1500m and ends 2min after having completed the 1500m
rating of gastrointestinal stress [during the 3 weeks of study phase]
1min before starting to drink the fluid, 2min before starting with the warm up, 2min before the test and 2min after having completed the 1500m
Rating of Perceived Exertion (RPE) [during the 3 weeks of study phase]
15s after the end of the warm up, 15s after having completed the 1500m