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Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment

Sponsor
Huazhong University of Science and Technology (Other)
Overall Status
Completed
CT.gov ID
NCT01559766
Collaborator
ShiYan Centre for Disease Control and Prevention (Other), Tufts Medical Center (Other)
403
Enrollment
1
Location
14
Duration (Months)
28.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    403 participants
    Time Perspective:
    Cross-Sectional
    Official Title:
    Estimating Dietary Vitamin A Requirement in Chinese Children by Stable-isotope Dilution Technique
    Study Start Date :
    Jul 1, 2009
    Actual Primary Completion Date :
    Jul 1, 2010
    Actual Study Completion Date :
    Sep 1, 2010

    Arms and Interventions

    Arm Intervention/Treatment
    4-6 years old group
    7-9 years old group

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      4 Years to 9 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • well-nourished children with normal serum retinol(>=1.40umol/L)
      Exclusion Criteria:

      • ongoing or previous illnesses,

      • having taken nutritional supplements within 3 months,

      • positive results in the fat absorption test or parasite test,

      • increased level of CRP (> 8 mg/L), or

      • lower serum level of retinol (< 1.40 umol/L)

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Shiyan Centre for Disease Control and Prevention Shiyan Hubei China 442500

      Sponsors and Collaborators

      • Huazhong University of Science and Technology
      • ShiYan Centre for Disease Control and Prevention
      • Tufts Medical Center

      Investigators

      • Principal Investigator: Xiufa Sun, BS, Tongji Medical College, Huazhong University of Science and Technology

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Xiufa Sun, Professor, Huazhong University of Science and Technology
      ClinicalTrials.gov Identifier:
      NCT01559766
      Other Study ID Numbers:
      • No.2008BAI58B03
      First Posted:
      Mar 21, 2012
      Last Update Posted:
      Mar 21, 2012
      Last Verified:
      Mar 1, 2012
      Keywords provided by Xiufa Sun, Professor, Huazhong University of Science and Technology
      Vitamin A
      Dietary requirement
      Dietary records
      Deuterated retinol dilution technique
      Chinese children
      Dietary intake of vitamin A
      Vitamin A liver reserves
      Additional relevant MeSH terms:
      Night Blindness
      Vitamin A Deficiency

      Study Results

      No Results Posted as of Mar 21, 2012