Difference of Gastric Microbiota in the Process of Correa's Model.

Sponsor

Shandong University (Other)

Overall Status

Unknown status

CT.gov ID

NCT02833363

Collaborator

(none)

Enrollment

Location

7.1

Duration (Months)

7.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Helicobater pylori plays an important role in the development of gastric cancer. Eradication therapy can reducing the morbidity of gastric cancer, but can't totally prevent it especially when atrophy and more serious precancerous lesions already happened. Prior studies found the gastric bacterial difference among gastritis, intestinal metaplasia and gastric cancer. However, they didn't reach an agreement. Correa's model is widely accepted in the development of gastric cancer. The pathological change makes a more suitable environment for bacteria to overgrowth. This study are designed to analyze the gastric microbial difference of non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, intraepithelial neoplasia and gastric cancer.

Condition or Disease	Intervention/Treatment	Phase
Gastric Microbiota Non-atrophic Gastritis Atrophic Gastritis Intestinal Metaplasia Intraepithelial Neoplasia Gastric Cancer Helicobacter Pylori

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Difference of Gastric Microbiota in the Process of Correa's Model.

Study Start Date :

Jul 1, 2016

Anticipated Primary Completion Date :

Dec 1, 2016

Anticipated Study Completion Date :

Feb 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
patients with non-atrophic gastritis
Patients with gastritis
Patients with intestinal metaplasia
Patients with intrepithelial neoplasia
Patients with non-cardia gastric cancer

Outcome Measures

Primary Outcome Measures

Difference of Gastric Microbiota in the Process of Correa's Model. [5 months]

Secondary Outcome Measures

Difference of Gastric Microbiota in the Process of Correa's Model. [5 months]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients go through a gastric endoscopy examination with non-atrophic gastritis, atrophic gastris, intestinal metaplasia, intraepithelial neoplasia and gastric cancer.
Did not take any antibiotics,PPI,probiotics and chinese herbs in the past one month,and took less than one week in the past three months before the gastroscopy examination.
Sign the informed consent.

Exclusion Criteria:

Had been taken Helicobacter pylori eradication therapy before.
Previous gastrointestinal surgery.
During the pregnancy and lactation period.
With any serious diseases like liver failure,heart failure,renal failure,malignant tumor,alcoholism or any other disease that may effect the result.
With any mental problems.