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Study on the Difference of Plasma microRNA Expression in Patients With Genetic Susceptibility to Mental Disorders

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University (Other)
Overall Status
Completed
CT.gov ID
NCT03999931
Collaborator
(none)
49
Enrollment
24
Actual Duration (Months)

Study Details

Study Description

Brief Summary

Schizophrenia (Schizophrenia,Sc), biphasic affective disorder (Bipolar disorder,BPD), major depression (major depressive disorder,MDD), anxiety disorder (Anxiety disorder,An) and other mental disorders have obvious family aggregation, with heritability of 60 -90%. This kind of common mental illness seriously affects the psychosomatic health and quality of life of patients, and places a great mental and economic burden on the society and family. At present, the diagnosis of mental illness is mainly based on clinical symptoms. With the development of molecular biology, genomics has become a new way to study mental illness. MicroRNA (miRNA) is a class of eukaryotic endogenously non-coding single-stranded RNA, which can regulate gene expression by binding to specific mRNA or regulating the protein translation process of specific mRNA. MiRNA widely exists in plasma and serum, and the type and quantity of miRNA in plasma and serum change with different physiological and disease conditions. It is reported that the expression profile of miRNA in brain tissue of schizophrenia is significantly different from that of normal subjects. In addition, the study found that the specific miRNA detected in peripheral blood can directly reflect the condition of the disease, which may use miRNA in peripheral blood as a clinical biological marker. In order to detect the expression of various miRNA in plasma, high throughput miRNA chip detection has become the first choice for primary screening. In this study, the investigators intend to detect the difference of miRNA expression in peripheral blood of different types of schizophrenia by high throughput miRNA chip, and analyze the correlation between them. It is hoped to provide the basis for the diagnosis and occurrence and development of clinical psychotic patients.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    49 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Other
    Official Title:
    The Second Affiliated Hospital, Zhejiang University
    Actual Study Start Date :
    Jan 1, 2014
    Actual Primary Completion Date :
    Jan 1, 2015
    Actual Study Completion Date :
    Dec 31, 2015

    Arms and Interventions

    Arm Intervention/Treatment
    schizophrenia with positive symptoms

    schizophrenia with positive symptoms
    schizophrenia with negative symptoms

    schizophrenia with negative symptoms
    bipolar disorder

    bipolar disorder
    depression

    depression
    panic disorder

    panic disorder
    obsessive-compulsive disorder

    obsessive-compulsive disorder
    control

    Outcome Measures

    Primary Outcome Measures

    1. The expression of mir-4687-3p in patients with PD is different from that in normal subjects. [July, 2016]

      The expression of mir-4687-3p in patients with PD is different from that in normal subjects.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    21 Years to 66 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    Meet the diagnostic criteria of DSM- V (see attached page for details); there is no history of blood transfusion within 1 month.

    Exclusion Criteria:

    Physical and nervous system diseases such as brain trauma; history of mental illness such as mental retardation; history of alcohol abuse and drug abuse.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Second Affiliated Hospital, School of Medicine, Zhejiang University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Second Affiliated Hospital, School of Medicine, Zhejiang University
    ClinicalTrials.gov Identifier:
    NCT03999931
    Other Study ID Numbers:
    • 2013-058
    First Posted:
    Jun 27, 2019
    Last Update Posted:
    Jun 27, 2019
    Last Verified:
    Jun 1, 2016
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Disease Susceptibility
    Genetic Predisposition to Disease
    Mental Disorders
    Psychotic Disorders

    Study Results

    No Results Posted as of Jun 27, 2019