Study on the Difference of Preoperative Related Parameters in Children With or Without Microcornea Within Less Than One Year Old
Study Details
Study Description
Brief Summary
This subject is mainly to study difference of Congenital cataract preoperative related parameters in children with or without Microcornea within Less than one year old. A total of 186 eyes of 117 people were collected with relevant ocular biological parameters, including age, horizontal diameter of the cornea, Eye axis, intraocular pressure, steep axis of corneal curvature, flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth. At present, because the definition of patients with small cornea is not clear enough, the study subjects are divided into 4 groups according to the horizontal corneal diameter of 9.0mm, 9.5mm, and 10.0mm, namely ≤9.0mm group, 99.5mm group, 9.510.0mm group and The >10.0mm group compares the differences between each other, and tries to provide a reference for the diagnosis of children with small cornea at a young age.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Corneal horizontal diameter ≤9.00mm group
|
Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth
observation
|
| Corneal horizontal diameter 9.00mm~9.50mm group
|
Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth
observation
|
| Corneal horizontal diameter 9.50mm~10.00mm group
|
Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth
observation
|
| Corneal horizontal diameter >10.00mm group
|
Device: Collect ocular biological parameters including age, corneal diameter, eye axis, intraocular pressure, steep&flat axis of corneal curvature, corneal thickness, lens thickness, anterior chamber depth
observation
|
Outcome Measures
Primary Outcome Measures
- horizontal diameter of the cornea [2015.5.1-2020.12.1]
Use a ruler to measure during surgery
Secondary Outcome Measures
- age [2015.5.1-2020.12.1]
- Eye axis [2015.5.1-2020.12.1]
A-type ultrasonic measuring instrument
- intraocular pressure [2015.5.1-2020.12.1]
i care handheld tonometer
- steep axis of corneal curvature [2015.5.1-2020.12.1]
Handheld eye curvature measuring instrument
- flat axis of corneal curvature [2015.5.1-2020.12.1]
Handheld eye curvature measuring instrument
- corneal thickness [2015.5.1-2020.12.1]
Handheld corneal thickness measuring instrument
- lens thickness [2015.5.1-2020.12.1]
A-type ultrasonic measuring instrument
- anterior chamber depth [2015.5.1-2020.12.1]
SS-OCT
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Congenital cataract children with or without Microcornea within Less than one year old
-
Complete collection of eye biological parameters before the first-stage Congenital cataract surgery
-
The nutritional status and development of the included subjects have no obvious defects
Exclusion Criteria:
-
congenital persistent pupilary membrane
-
lens sublaxation or lens dislocotion
-
Marfan syndrome
-
Down's Syndrome
-
Peters abnormality
-
Fevr
-
history of obvious eye trauma
-
obvious macula
-
long-term (local or systemic) use of glucocorticoids.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Wenzhou Medical University | Hangzhou | Zhejiang | China | 313000 |
Sponsors and Collaborators
- Wenzhou Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
- Evaluation of the safety of sclerotomy incision in patients with choroidal colobomas with/without associated microcornea
- Surgical Outcome of Congenital Cataract in Eyes With Microcornea. J Pediatr Ophthalmol Strabismus.
- Unique presentation of congenital cataract concurrent with microcornea, microphthalmia plus posterior capsule defect in monozygotic twins caused by a novel GJA8 mutation.
Publications
- Liu T, Zhang M, Xu B, Wang W, Lee J, Gao Y, Zhang X. Evaluation of the safety of sclerotomy incision in patients with choroidal colobomas with/without associated microcornea. Retina. 2014 Nov;34(11):2300-5. doi: 10.1097/IAE.0000000000000227.
- Matalia J, Shirke S, Shetty KB, Matalia H. Surgical Outcome of Congenital Cataract in Eyes With Microcornea. J Pediatr Ophthalmol Strabismus. 2018 Jan 1;55(1):30-36. doi: 10.3928/01913913-20170703-13. Epub 2017 Oct 9.
- Zhang H, Chen Z, He K, Chang P, Zhao Y, Huang X, Li J, Jin Z, Zhao YE. Unique presentation of congenital cataract concurrent with microcornea, microphthalmia plus posterior capsule defect in monozygotic twins caused by a novel GJA8 mutation. Eye (Lond). 2019 Apr;33(4):686-689. doi: 10.1038/s41433-018-0277-y. Epub 2018 Nov 29.
- Microcornea