The Differences Between Gonadal and Extra-gonadal Malignant Teratomas

• Sponsor: Shanghai 10th People's Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT04555395
• Collaborator: (none)
• Enrollment: 3,799
• Actual Duration (Months): 564

Study Details

Study Description

Brief Summary

A tumor comprising of different types of tissues (such as hair, muscle, bone, etc.) is known as a teratoma. It is a type of germ cell (cells that make sperm or eggs) tumor. When these germ cells have rapid cancerous growth, then such a teratoma is called a malignant teratoma. We have studied the differences between gonadal and extra-gonadal malignant teratomas and the effects of chemotherapy in both genders.

Methods: The samples of 3799 male and 1832 female patients with malignant teratoma samples, between the ages of 1 and 85+ years, were selected from the years 1973 to 2014. Trends in incidence, estimated prevalence, incidence rates, and frequency were calculated in gonadal and extra-gonadal tumors with age adjustment. The fiveyear observed, expected, and relative survival rates were analyzed to study the prognosis.

Condition or Disease	Intervention/Treatment	Phase
SEER Database	Other: survival rates

Study Design

• Study Type: Observational
• Actual Enrollment: 3799 participants
• Observational Model: Case-Crossover
• Time Perspective: Retrospective
• Official Title: The Differences Between Gonadal and Extra-gonadal Malignant Teratomas in Both Genders and the Effects of Chemotherapy
• Actual Study Start Date: Jan 1, 1973
• Actual Primary Completion Date: Jan 1, 2020
• Actual Study Completion Date: Jan 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
gonadal	Other: survival rates; survival rates
extra-gonadal	Other: survival rates; survival rates
chemotherapy	Other: survival rates; survival rates
without chemotherapy	Other: survival rates; survival rates

Outcome Measures

Primary Outcome Measures

1. survival rates [1973-2014]

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

The registry used in our study was the SEER 9 registries Custom Data (with additional treatment fields), Nov 2016 Submission (1973-2014) < Katrina/Rita Population Adjustment> - Linked to County Attributes -Total United States, 1969-2015 Counties, National Cancer Institute, DCCPS (Division of Cancer Control and Population Sciences), Surveillance Research Program, released April 2017, based on the November 2016 submission.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Shanghai 10th People's Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Zhang Manna, Shanghai 10th People's Hospital, Shanghai 10th People's Hospital
• ClinicalTrials.gov Identifier: NCT04555395
• Other Study ID Numbers: malignant teratomas
• First Posted: Sep 18, 2020
• Last Update Posted: Sep 18, 2020
• Last Verified: Sep 1, 2020

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Teratoma

Study Results

No Results Posted as of Sep 18, 2020