Differences in ECG- vs. proLonged cardIac MonItor-DeTected Atrial Fibrillation in STROKE Patients (DELIMIT AF-STROKE)
Study Details
Study Description
Brief Summary
The present study is an investigator-initiated, single-center, retrospective study based on data from the London Ontario Stroke Registry (LOSR), aiming to compare the characteristics and outcomes of ECG-detected and Device-Detected atrial fibrillation in patients with ischemic stroke and transient ischemic attack.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients with ischemic stroke and transient ischemic attack (TIA) without known atrial fibrillation (AF) are investigated with Prolonged Cardiac Monitoring (PCM) to detect AF. It is unclear if AF detected on 12-lead ECG after stroke occurrence bears the same risk of stroke as Device-detected AF. The investigators hypothesize, that Device-detected AF has a lower risk of ischemic stroke recurrence. The investigators will conduct a retrospective analysis of prospectively collected data from consecutive patients enrolled in the London Ontario Stroke Registry, (Ontario, Canada). The primary outcome will be a recurrent ischemic stroke at the end of the available follow-up window. The investigators will include ischemic stroke and TIA patients with ECG-detected AF and those with Device-detected AF on at least 7 days of Holter monitoring.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| ECG-Detected AF Patients with atrial fibrillation detected on 12-lead ECGs done post-stroke |
Diagnostic Test: ECG
Electrocardiogram
|
| Device-Detected AF Patients with atrial fibrillation detected on prolonged Holter monitoring lasting at least 7 days. |
Diagnostic Test: Prolonged cardiac monitoring
Prolonged cardiac monitoring
|
Outcome Measures
Primary Outcome Measures
- Number of Participants with Recurrent Ischemic Stroke at End of available Follow-up Time [Duration of follow-up - minimum of 3 months after the first encounter with the stroke team]
Documented recurrent ischemic stroke
Secondary Outcome Measures
- Death [Duration of follow-up - minimum of 3 months after the first encounter with the stroke team]
Number of patients dead at the end of the available follow-up
- Readmission for decompensated AF or heart failure [Duration of follow-up - minimum of 3 months after the first encounter with the stroke team]
Prevalence of readmission for decompensated AF or heart failure (HF) in each group
- Prevalence of risk factors, cardiovascular comorbidities, and structural heart disease [Documented at baseline.]
Proportion with vascular risk factors, cardiovascular comorbidities, and structural heart disease in each group
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age ≥18 years
-
Patient with a diagnosis of ischemic stroke or TIA.
-
ECG-diagnosed AF or PCM-detected AF post ischemic stroke or TIA
Exclusion Criteria:
-
Individuals younger than18 years-old
-
Patients without IS or TIA diagnosis
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Heart & Brain Lab, Western University | London | Ontario | Canada | N6A 5A5 |
Sponsors and Collaborators
- Lawson Health Research Institute
Investigators
- Principal Investigator: Luciano Sposato, MD, MBA (PI), London Health Sciences Centre, Western University (London, ON. Canada)
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ReDA ID 13446