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Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics

Sponsor
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (Other)
Overall Status
Completed
CT.gov ID
NCT06118489
Collaborator
(none)
50
Enrollment
1
Location
5
Actual Duration (Months)
10.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects. Sevoflurane has been shown to reduce airway resistance more than halothane and isoflurane. Desflurane is difficult to use as an induction agent due to its harsh and extremely pungent odor and airway irritating effect. However, it has been shown that the risk of cough, respiratory arrest and laryngospasm is no different from sevoflurane when administered after intravenous induction. Although it irritates the airway, it is thought to have a bronchodilation effect as it stimulates the sympathetic system.

In spinal surgeries, prone position is required to access the operating field. When the patient is placed in the prone position, pulmonary physiology are affected. In the prone position, V/Q mismatch decreases and arterial oxygenation increases. However, lung compliance decreases and the peak inspiratory pressure required to reach the required tidal volume increases. The main purpose of this study is the effect of volatile agents on lung mechanics and oxygenisation in the prone position.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    50 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Evaluation of the Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics in Spinal Surgery.
    Actual Study Start Date :
    Jan 1, 2023
    Actual Primary Completion Date :
    Jun 1, 2023
    Actual Study Completion Date :
    Jun 1, 2023

    Arms and Interventions

    Arm Intervention/Treatment
    sevoflurane
    desflurane

    Outcome Measures

    Primary Outcome Measures

    1. compliance [2 hour]

      pulmonary compliance before, during and after prone position

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 65 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • 18-65 years old

    • ASA1-2

    • Patients planned to undergo spinal surgery

    Exclusion Criteria:

    • 1 - Lung disease

    • BMI 35 and above

    • Smokers

    • Those under the age of 18 and over the age of 65

    • Hepatorenal disease

    • Reynaud's disease

    • Burger disease

    • Hypotensive patient

    • Neuromuscular disease

    • Those who have had thoracic surgery before

    • Those with bad Allen test results

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Yadigar Yılmaz Istanbul Turkey 34230

    Sponsors and Collaborators

    • Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Yadigar Yılmaz, MD, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
    ClinicalTrials.gov Identifier:
    NCT06118489
    Other Study ID Numbers:
    • HamidiyeKAEK-98172
    First Posted:
    Nov 7, 2023
    Last Update Posted:
    Nov 7, 2023
    Last Verified:
    Oct 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No

    Study Results

    No Results Posted as of Nov 7, 2023