Clincosm LogoSign in Get a demo

Differential Diagnosis of STA-PSV in Thyrotoxicosis

Sponsor
xiaolong zhao (Other)
Overall Status
Completed
CT.gov ID
NCT01227499
Collaborator
Zhongda Hospital (Other), Fudan University (Other)
169
Enrollment
1
Location
17
Duration (Months)
9.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different. Measurement of iodine uptake is the gold standard to differential diagnosis the thyroiditis or Graves's disease. But the iodine uptake is limited for its availability in china and easily influenced by medicine or food contained iodine.The blood pattern of thyroid CFDS is useful for differentiate the cause of thyrotoxicosis.Most previous studies using the descriptive pattern of thyroid CFDS is easily varied by operator subjective judgement. This study is focus on the role of peak systolic velocity of thyroid superior artery in differential diagnosis of thyrotoxicosis. Methods: Patients with thyrotoxicosis symptoms without recent medicine history were enrolled in two clinical center. Its thyroid function, iodine uptake , CFDS of thyroid and peak systolic velocity of thyroid superior artery is detected. Thyrotoxicosis is defined as TSH level below the low value of normal range. Graves disease is defined as the typical symptoms of graves disease such as graves ophthalmopathy or increased iodine uptake. Thyroiditis is defined as lack of typical symptoms of graves disease or decreased iodine uptake.We use receiver operator curve(ROC) to evaluate its diagnosis value

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    169 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease
    Study Start Date :
    Jun 1, 2010
    Actual Primary Completion Date :
    Nov 1, 2011
    Actual Study Completion Date :
    Nov 1, 2011

    Outcome Measures

    Primary Outcome Measures

    1. mean STA-PSV [2014-04-07]

      the mean STA-PSV

    2. uptake of iodine [December 1, 2013]

    Secondary Outcome Measures

    1. PSV [December 1, 2013]

    Other Outcome Measures

    1. thyroid funciton [December 1, 2013]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    15 Years to 85 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • newly diagnosed without taking any antithyroid drug or beta receptor blocker with TSH level below the lower limits of reference range

    • is willing to be enrolled

    Exclusion Criteria:

    • unwilling

    • taking antithyroid drug or beta receptor blocker

    • taking foods or medicine rich in iodine in 8 weeks

    • women with pregnant or lactation

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Xiaolong Zhao Shanghai Shanghai China 200040

    Sponsors and Collaborators

    • xiaolong zhao
    • Zhongda Hospital
    • Fudan University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    xiaolong zhao, endocrinology department, Huashan Hospital
    ClinicalTrials.gov Identifier:
    NCT01227499
    Other Study ID Numbers:
    • huashan001
    First Posted:
    Oct 25, 2010
    Last Update Posted:
    May 5, 2014
    Last Verified:
    May 1, 2014
    Additional relevant MeSH terms:
    Graves Disease
    Thyroiditis
    Thyrotoxicosis
    Systolic Murmurs

    Study Results

    No Results Posted as of May 5, 2014