Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study
Study Details
Study Description
Brief Summary
The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.
With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| All cohort Initially healthy patients in General Practise Research Database (GPRD) meeting the inclusion criteria at any point between 1st January 2001 and 25th March 2010 |
Outcome Measures
Primary Outcome Measures
- Rate of stable angina [Cohort followed up for average of 7 years]
Incidence of stable angina in study population
Secondary Outcome Measures
- Rate of unstable angina [Cohort followed up for average of 7 years]
Incidence of unstable angina in study population
Other Outcome Measures
- Rate of non ST elevation myocardial infarction [Cohort followed up for average of 7 years]
Incidence of non ST elevation myocardial infarction
Eligibility Criteria
Criteria
Inclusion Criteria:
- Aged 30 to 100, had at least one year of electronic health record data which meet General Practice Research Database data quality standards
Exclusion Criteria:
- No record indicating any cardiovascular disease phenotypes
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University College London | London | Greater London | United Kingdom | WC1E 6BT |
Sponsors and Collaborators
- University College, London
- Wellcome Trust
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Ebrahim S, Sung J, Song YM, Ferrer RL, Lawlor DA, Davey Smith G. Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study. BMJ. 2006 Jul 1;333(7557):22. Epub 2006 Jun 6. Erratum in: BMJ. 2006 Sep 2;333(7566):468.
- Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, Collins R, Thompson SG, Danesh J. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009 Nov 11;302(18):1993-2000. doi: 10.1001/jama.2009.1619.
- Prospective Studies Collaboration, Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R, Collins R. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007 Dec 1;370(9602):1829-39. Review. Erratum in: Lancet. 2008 Jul 26;372(9635):292.
- CALIBER-12-01