Differentiation of Tubular Adenoma and Colonic Innominate Groove Under EC Endoscopy
Study Details
Study Description
Brief Summary
This study is to analyze the characteristics of the IIIL opening of the duct in tubular adenoma and the colonic innominate groove under EC endoscopy, in order to improve the ability to tell lesions and the colonic innominate groove under EC endoscopy (Endocytoscopy).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This is a prospective cohort study. The recruitment time for all participants will be 4 months. The tubular adenoma group and the colonic innominate groove group will be paired in a 1:2 ratio, with 32 lesions of tubular adenoma and 64 adjacent innominate groove. It is expected that there will be 32 cases and a total of 96 observation subjects. Analyze and compare the characteristics of the opening of the IIIL duct in tubular adenomas and the colonic innominate groove under EC endoscopy, in order to summarize and differentiate them.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| The tubular adenoma group The anatomical site was determined, and the size and morphology of the polyps were observed. The classification of the microvascular ECV of the polyps and its adjacent normal mucosal microvascular ECV (white light+NBI) was observed, and methylene blue staining was used to approach and magnify the glandular duct opening to observe the IIIL type (pit pattern). Magnified to the maximum magnification of EC endoscopy to the clearest cell level (approximately 520 times), and observed the morphology of the opening of the IIIL type glandular duct and the opening of the colonic innominate groove, including the morphology of cell cytoplasm and nucleus, proportion of opening length to field of view (more than 1 field of view is calculated as 1.0), and ratio of maximum to minimum opening diameter; Distribution characteristics of glandular duct openings. |
Procedure: The tubular adenoma group
Biopsy or removal of polyps for pathological examination. Collect baseline data such as gender, age, BMI, etc. If the pathology confirms a pure tubular adenoma, the observed object will be included in the group for final comparative analysis.
Other Names:
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| the colonic innominate groove group The methylene blue staining area of the normal mucosa adjacent to the polyp was observed to identify the colonic innominate groove.Magnified to the maximum magnification of EC endoscopy to the clearest cell level (approximately 520 times), and observed the morphology of the opening of the IIIL type glandular duct and the opening of the colonic innominate groove, including the morphology of cell cytoplasm and nucleus, proportion of opening length to field of view (more than 1 field of view is calculated as 1.0), and ratio of maximum to minimum opening diameter; Distribution characteristics of glandular duct openings. |
Outcome Measures
Primary Outcome Measures
- Proportion of opening length to field of view [10 minutes after the observation of Endocytoscopy]
(more than 1 field of view is calculated as 1.0)
Secondary Outcome Measures
- Observation of anatomical location [10 minutes after the observation of Endocytoscopy]
The anatomical site (ileocecal region, ascending colon, hepatic flexure, transverse colon, Colonic splenic region, descending colon, sigmoid colon, rectum)
Other Outcome Measures
- Morphology of IIIL type glandular opening and unnamed sulcus opening [10 minutes after the observation of Endocytoscopy]
Morphology of IIIL type glandular opening and unnamed sulcus opening after methylene blue staining.Linear or circular pit pattern.
- Distribution characteristics of glandular opening [10 minutes after the observation of Endocytoscopy]
Magnified to the maximum magnification of EC endoscopy to the clearest cell level (approximately 520 times), and observed the morphology of the opening of the IIIL type glandular duct and the opening of the colonic innominate groove, including the morphology of cell cytoplasm and nucleus, and distribution characteristics of glandular duct openings. Regular or irregular？
Eligibility Criteria
Criteria
Inclusion Criteria:
- Cases of colorectal polyps discovered in our hospital and undergoing EC endoscopic examination.
Exclusion Criteria:
- 1.Suffering from hereditary polyposis or inflammatory bowel disease, severe intestinal inflammation, or difficulty recognizing normal intestinal mucosa;
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History of methylene blue allergy;
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Patients who have participated or are currently participating in other clinical trials within the first 4 weeks of enrollment;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | the First Hospital of Jilin University | Chang chun | Ji Lin | China | 130021 |
Sponsors and Collaborators
- Jilin University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 130025