Comparative Study of Postprocessing Imaging Systems for Diminutive Colonic Polyps
Study Details
Study Description
Brief Summary
Several novel imaging technologies are currently used for detection and differentiation of colonic polyps during colonoscopy, such as NBI (Olympus), FICE (Fujinon), and i-Scan (Pentax).
Several previous studies have indicated that NBI without magnification can be useful for real-time differentiation of diminutive colonic neoplasias.
To date, however, there are no studies comparing NBI with other imaging systems (FICE or i-Scan) for differentiation of diminutive colonic polyps.
The study objectives are to compare the diagnostic efficacy of NBI with that of i-Scan in real-time prediction of diminutive colonic polyps.
In this prospective pilot study, diminutive colonic polyps detected during colonoscopy will be observed with conventional colonoscopy, thereafter will be observed with new imaging systems.
Sensitivity, specificity, and diagnostic accuracy of both NBI and i-Scan will be assessed by reference to histological results obtained by endoscopic biopsy or polypectomy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: NBI observation
|
Other: Observation using NBI system
NBI system can improve the patterns of mucosal surface and vascularity of colonic polyp.
Other Names:
|
| Experimental: i-Scan observation
|
Other: Observation using i-Scan system
I-Scan system can improve the patterns of mucosal surface and vascularity of colonic polyp.
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Diagnostic efficacy [about 1 year]
Sensitivity, specificity, and diagnostic accuracy
Eligibility Criteria
Criteria
Inclusion Criteria:
-
screening or surveillance colonoscopy
-
age over 18
-
informed consent
Exclusion Criteria:
-
history of inflammatory bowel diseases
-
history of hereditary colorectal cancers and polyposis syndrome
-
inability to give informed consent
-
use of antiplatelet agent and anticoagulants
-
pregnancy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Soon Chung Hyang University, Cheonan hospital | Cheonan | Choongnam | Korea, Republic of | 330-721 |
Sponsors and Collaborators
- Soon Chun Hyang University
Investigators
- Principal Investigator: Chang Kyun Lee, MD, PhD, Soon Chun Hyang University
Study Documents (Full-Text)
None provided.More Information
Publications
- Hoffman A, Kagel C, Goetz M, Tresch A, Mudter J, Biesterfeld S, Galle PR, Neurath MF, Kiesslich R. Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy. Dig Liver Dis. 2010 Jan;42(1):45-50. doi: 10.1016/j.dld.2009.04.005. Epub 2009 May 26.
- Rastogi A, Pondugula K, Bansal A, Wani S, Keighley J, Sugar J, Callahan P, Sharma P. Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology. Gastrointest Endosc. 2009 Mar;69(3 Pt 2):716-22. doi: 10.1016/j.gie.2008.09.058.
- Rex DK. Narrow-band imaging without optical magnification for histologic analysis of colorectal polyps. Gastroenterology. 2009 Apr;136(4):1174-81. doi: 10.1053/j.gastro.2008.12.009. Epub 2008 Dec 10.
- SCHCH2010L2