Evaluation of Discarded Laboratory Pathological Specimens and Media
Study Details
Study Description
Brief Summary
The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture conditions.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
We propose to identify a group of parameters that have significant predictive value for assisted reproductive technology outcomes. We seek to test, standardize and implement better methods for the freezing of oocytes and sperm prior to these techniques being used in the clinical setting. We seek to develop new methods to optimize the determination of genes and chromosomes in gametes. We hope to develop new cell surgery or micromanipulation techniques (e.g. use of cell drills and lasers in order to enhance the efficiency of procedures such as ICSI, assisted hatching, biopsy) as well as other manipulations. We will test the safety and efficiency of micro fluidics and automation in the Embryology lab. This has the potential to reduce cost, human errors, temperature and physical changes. We hope to develop new methods and media and media supplements normally found in the reproductive tract that allow for higher survival of gametes in vitro. We will also test the proficiency of laboratory staff members on techniques and/or procedures performed in the in-vitro fertilization laboratory. We will perform Quality Control to review how changes in temperature and setting can effect specimens
Study Design
Outcome Measures
Primary Outcome Measures
- Methods for the freezing of ooyctes and sperm [duration of study]
To test, standardize and implement better methods for the freezing of ooyctes and sperm prior to these techniques being used in the clinical setting.
Secondary Outcome Measures
- New methods of gene and chromosome analysis [duration of study]
The development of new methods to optimize the determination of genes and chromosomes in gametes.
Eligibility Criteria
Criteria
Inclusion Criteria:
none
Exclusion Criteria:
none
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Reproductive Medicine Assoicates of New Jersey | Basking Ridge | New Jersey | United States | 07920 |
Sponsors and Collaborators
- Reproductive Medicine Associates of New Jersey
Investigators
- Principal Investigator: Richard T Scott, MD, Reproductive Medicine Associates of New Jersey
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- RMA-00-14