Disparities Among Liver Transplant Patients

Sponsor

Mayo Clinic (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05981196

Collaborator

(none)

100

Enrollment

Location

Anticipated Duration (Months)

2.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to inform healthcare interventions to reduce the disparities in liver transplant listing and in transplantation.

Condition or Disease	Intervention/Treatment	Phase
End Stage Liver DIsease

Detailed Description

Aim 1. Establish a longitudinal cohort of patients with end-stage liver dysfunction.

Aim 2. Examine interpersonal and structural factors associated with liver transplant evaluation and listing by patient characteristics (e.g., race, ethnicity, SES, gender).

Aim 3. Examine the use of stigmatizing language among patients undergoing liver transplant based on their demographic characteristics (e.g., race, ethnicity, SES, gender).

Study Design

Study Type:

Observational

Anticipated Enrollment :

100 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Individual and Structural-level Determinants Associated With Disparities Among Liver Transplant Patients

Anticipated Study Start Date :

Sep 1, 2023

Anticipated Primary Completion Date :

Sep 1, 2024

Anticipated Study Completion Date :

Sep 1, 2026

Arms and Interventions

Arm	Intervention/Treatment
Liver Transplant Patients Subjects with end-stage liver disease and being referred for transplant evaluation will fill out questionnaires about their background, emotions, and behaviors.

Outcome Measures

Primary Outcome Measures

Liver transplant waiting list [Approximately one year]
Number of subjects listed on the liver transplant waiting list
Organ transplantation [Approximately one year]
Number of subject to receive an organ transplantation

Secondary Outcome Measures

Survival [Approximately one year post-transplant, or until you are removed from the transplant list]
Total number of subject alive
Graft survival at six months [Six months post transplant]
Total number of subject to have a functioning graft at six months post transplant
Graft survival at one year [One year post transplant]
Total number of subject to have a functioning graft at one year post transplant

Other Outcome Measures

Mortality [Approximately one year post-transplant, or until you are removed from the transplant list]
Total number of subject deaths
Hospital length of stay [Approximately one year post-transplant, or until you are removed from the transplant list]
Total number of days subjects were admitted to the hospital
ICU length of stay [Approximately one year post-transplant, or until you are removed from the transplant list]
Total number of days subjects were admitted to Intensive Care Unit (ICU)
30-day readmission [Approximately one year post-transplant, or until you are removed from the transplant list]
Number of subjects to experience a 30-day readmission

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

All

Inclusion Criteria:

Patients with end-stage liver, kidney, or cardiac dysfunction.

Exclusion Criteria:

Patients with more than one system with end stage organ dysfunction, dementia, cognitive or sensory impairment, prior solid organ transplant.
Patients with potential medical exclusions for transplant.