Diverse Ancestry Study in IBD
Study Details
Study Description
Brief Summary
Objective:
To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD in diverse ancestries:
African, African American, Black, Afro-Caribbean, Afro-Latino/a/x, Latino/a/x, Hispanic, or any other Black or Latin or indigenous ancestry.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Background:
Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among diverse populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in individuals who self-identify as African, African American, Black, Afro-Caribbean, Afro-Latino/a/x, Latino/a/x, Hispanic, or any other Black or Latin or indigenous ancestry.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| IBD Subjects Self-identify as: Black, African, African American, Afro-Caribbean, Afro-Latino/a/x, or Hispanic/Latinx, Afro-Latino/a/x or any other Black or Latin or Indigenous ancestry Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U)) Any age |
Genetic: Blood or saliva sample collection
Blood or saliva sample & clinical data collection
|
| Controls Self-identify as: Black, African, African American, Afro-Caribbean, Afro-Latino/a/x, or Hispanic/Latinx, Afro-Latino/a/x or any other Black or Latin or Indigenous ancestry No personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss Any age |
Genetic: Blood or saliva sample collection
Blood or saliva sample & clinical data collection
|
Outcome Measures
Primary Outcome Measures
- Genetics studies in diverse ancestries [2022-2027]
Whole Exome Sequencing (+/- other sequencing) is planned to assess genetic diversity in diverse populations.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Subject must self-identify as African, African American, Black, Afro-Caribbean, Afro-Latino/a/x, Latino/a/x, Hispanic, or any other Black or Latin or indigenous ancestry
-
Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined)
-
Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U))
-
Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
-
Any age
Exclusion Criteria:
-
Doesn't self-identify as African, African American, Black, Afro-Caribbean, Afro-Latino/a/x, Latino/a/x, Hispanic, or any other Black or Latin or indigenous ancestry
-
Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sinai Health System | Toronto | Ontario | Canada | M5G 1X5 |
Sponsors and Collaborators
- Mount Sinai Hospital, Canada
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
- Principal Investigator: Mark Silverberg, MD PhD, Sinai Health System
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 02-0234-E
- U01DK062423