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DNA Methylation and 1-C Metabolism Nutrient Intake

Sponsor
Cancer Council Victoria (Other)
Overall Status
Completed
CT.gov ID
NCT03227003
Collaborator
(none)
5,983
Enrollment
24
Actual Duration (Months)

Study Details

Study Description

Brief Summary

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays.

The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    5983 participants
    Observational Model:
    Other
    Time Perspective:
    Cross-Sectional
    Official Title:
    Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood
    Actual Study Start Date :
    Jan 1, 2014
    Actual Primary Completion Date :
    Dec 31, 2015
    Actual Study Completion Date :
    Dec 31, 2015

    Outcome Measures

    Primary Outcome Measures

    1. Blood DNA methylation [2014-2015]

      Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay

    Secondary Outcome Measures

    1. Blood DNA methylation [2014-2015]

      Methylation of DNA from peripheral blood, LINE-1, Alu, Sat2

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    27 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study

    • Completed a 121-item Food Frequency Questionnaire

    • Had a blood DNA sample with a measure of methylation

    Exclusion Criteria:
    • Missing data in any of the outcome, exposure, or confounders (N=797 excluded)

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Cancer Council Victoria

    Investigators

    • Principal Investigator: Graham G Giles, PhD, Cancer Council Victoria

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Roger Milne, Head, Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
    ClinicalTrials.gov Identifier:
    NCT03227003
    Other Study ID Numbers:
    • CEID_methylation_1
    First Posted:
    Jul 24, 2017
    Last Update Posted:
    Jul 24, 2017
    Last Verified:
    Jul 1, 2017
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No

    Study Results

    No Results Posted as of Jul 24, 2017