Does Homebrewing Beer Affect Urinary Tract Symptoms and Bladder Cancer
Study Details
Study Description
Brief Summary
In this study, investigators aim to reveal the harmful effects of increasing consumption of homemade beer in recent years on the urinary tract. The high amount of carbonyl compounds in the content of homemade beer has been proven by studies. In this study, which will be conducted in the form of a questionnaire, it is aimed to evaluate the effects of the consumption of homemade beer and the long-term exposure of the urinary system to carbonyl compounds.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Homemade and craft beers are perceived as a popular alternative to beers produced on a larger scale in recent years, due to the choice of consumers according to different taste preferences and the raw materials used for brewing. According to nationally representative survey data from the American Homebrewers Association (AHA), the U.S. had an estimated 1.1 million homebrew brewers in 2017, with annual homebrew beer production in excess of 1.4 million barrels (about 1% of annual U.S. beer production). Again in 2017, 40% of home brewers started production within the last 4 years. Due to the prohibitions that have arisen due to the pandemic all over the world, the production of homemade beer has reached its peak today. In recent years, home-made beer consumption has gained popularity in parallel with low-alcohol and non-alcoholic beers, which are prone to microbial spoilage, due to the ease of access to the material, financial returns and hobby acquisition.
Homemade beer is typically more susceptible to spoilage as it is not pasteurized or sterile filtered. The microbiota, which is associated with organic raw materials, fruits, herbs, honey, spices and vegetables, and non-traditional starch-rich ingredients added to produce different aromas and flavors, increases the risk of spoilage. In addition, home brewers often lack the advantages of a sophisticated microbiological laboratory, and optimal temperature control during brewing and storage cannot be guaranteed. In addition to the fermentation conditions (time and temperature), yeast strain and mash composition (types of grain used in malting, mashing/boiling conditions) can also affect the chemical profile of beer, resulting in a wide variety of components. Carbonyl compounds [acetaldehyde, acrolein, ethyl carbamate (EC) and formaldehyde] are particularly toxic compounds that can occur. Acetaldehyde, acrolein, and formaldehyde are highly reactive due to their electrophilic nature, so they easily react with biological nucleophilic targets such as proteins, RNA, and DNA.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Consumption Patients consuming homemade beer |
Dietary Supplement: Homemade beer
The data of patients who consume and do not consume homemade beer will be cross-sectionally evaluated and compared.
Other Names:
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| Not consumption Patients are not consuming homemade beer |
Dietary Supplement: Homemade beer
The data of patients who consume and do not consume homemade beer will be cross-sectionally evaluated and compared.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Rates of urinary tract symptoms [3 months]
Rates of urinary tract symptoms who consumed the homemade beer
- Rates of bladder cancer [3 months]
Rates of bladder cancer who consumed the homemade beer
Eligibility Criteria
Criteria
Inclusion Criteria:
- Homemade beer consumption and not consumption
Exclusion Criteria
- Bleeding disorders
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ankara Training and Research Hospital | Ankara | Altindag | Turkey | 06230 |
Sponsors and Collaborators
- Ankara Training and Research Hospital
Investigators
- Principal Investigator: Ali Kaan Yildiz, Ankara Training and Resarch Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CB2021