Doppler at the Diagnosis in Predicting Perinatal Outcomes in Early and Late-onset Fetal Growth Restriction
Study Details
Study Description
Brief Summary
When a FGR is diagnose, the challenge in his monitoring is to assess the benefit-risk balance between continuing the pregnancy in order to limit complications related to prematurity and birth in order to minimize any risk of fetal death in utero. By able to know the characteristics of fetal deteriorations and its relationship with fetal and neonatal outcomes could be a thankful help in this decision. The placental insufficiency is by far the most common cause of FGR (32)(miller 2008). This effect can be documented thanks to ultrasound examinations to study fetal growth and Doppler of umbilical arteries for the placenta, the middle cerebral artery for the brain perfusion and the Ductus Venosus for the cardiac effects of placental dysfunction. The apparition of Doppler abnormalities suggests a deterioration of the disease and leads to several changes in clinical FGR management. Nevertheless, at this time, very few studies allow us to predict the time util the degradation and their impact on perinatal outcomes.
The primary aim of this study was to evaluate the performance of the Doppler at the time of diagnosis in predicting the outcome of pregnancies. The secondary aim was to evaluate the performance of Doppler performed at any time during pregnancy and studied independently in predicting outcome of pregnancies
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Early fetal growth restriction Fetal growth restriction diagnosed before 32 SA |
Other: Ultrasound
Doppler mesure
|
| Late fetal growth restriction Fetal growth restriction diagnosed after 32 SA |
Other: Ultrasound
Doppler mesure
|
Outcome Measures
Primary Outcome Measures
- evaluate the performance of the Doppler at the time of diagnosis in predicting the outcome of pregnancies [during pregnancy (6 month per patient maximum)]
Secondary Outcome Measures
- evaluate the performance of Doppler performed at any time during pregnancy and studied independently in predicting outcome of pregnancies [during pregnancy (6 month per patient maximum)]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Fetal growth restriction of antenatal diagnosis
Exclusion Criteria:
- Twin pregnancies, non-isolated IUGR, post-natal diagnosis of FGR and incomplete records
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Maternite Regionale et Universitaire de Nancy | Nancy | Meurthe-et-moselle | France | 54000 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022PI187-343