Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion
Study Details
Study Description
Brief Summary
Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion.
Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| healthy pregnant woman healthy pregnant woman |
Other: Doppler ultrasound measurement of changes in uterine artery blood flow
Doppler ultrasound measurement of changes in uterine artery blood flow
|
| Pregnant women with recurrent pregnancy loss Spontaneous abortion of three or more consecutive sexual partners |
Other: Doppler ultrasound measurement of changes in uterine artery blood flow
Doppler ultrasound measurement of changes in uterine artery blood flow
|
Outcome Measures
Primary Outcome Measures
- Pulsatility index [it can be monitored for up to 12 weeks]
Pulsatility index of the left and right main uterine arteries
- Resistive index [it can be monitored for up to 12 weeks]
Resistive index of the left and right main uterine arteries
- Systolic-to-diastolic ratio [it can be monitored for up to 12 weeks]
Systolic-to-diastolic ratio of the left and right main uterine arteries
Eligibility Criteria
Criteria
Healthy pregnant women Group
Inclusion Criteria:
-
Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
-
Complete maternal clinical data;
Exclusion Criteria:
-
The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
-
multiple pregnancy;
-
Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
-
Patients who have chronic diseases or are receiving chronic treatment.
Pregnant women with recurrent pregnancy loss Group
Inclusion Criteria:
-
Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
-
Complete maternal clinical data;
-
There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times;
Exclusion Criteria:
-
The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
-
multiple pregnancy;
-
Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
-
Patients who have chronic diseases or are receiving chronic treatment.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Second Affiliated Hospital of Wenzhou Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SAHoWMU-CR2023-07-208