Dosage of Propofol Based on Lean Body Weight
Study Details
Study Description
Brief Summary
Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the given doses and the body mass index will be evaluated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the doses given and the body mass index will be evaluated. In our study, we aimed to evaluate the effects of Propofol dose according to lean body weight by evaluating patients with bodymass index below 35.Patients who will be induction of anesthesia with propofol will have a body analysis with Tanita before the operation. Patients' height, weight, age, gender and other general information will be recorded. Total body weight (TBW), ideal body weight (IBW) and lean body weight (LBW) of the patients will be calculated. Patients over the age of 18 who will be operated under general anesthesia for 2-6 hours will be included. Patients with propofol allergy or contraindicated to propofol are included in the study. In order to decide and try the most appropriate weight-based scalar for propofol dosing for anesthesia induction to be evaluated by specifying patients who need additional propofol during intubation in the study, Ingrande et al. 80 patients with a mean body mass index [BMI] between 18-35 and Bispectoral index (BIS). ) monitorization, propofol infusion (100 mg/kg/hour) will be started according to total body weight, and the infusion will be stopped with a BIS value between 50 and 40, and the elapsed time will be recorded. Routine anesthesia applications will be performed with neuromuscular blocker applied. The total dose of Propofol given; the dose applied to kilograms will be calculated according to TBW, IBW and LBW. And the relationship between the doses given and the body mass index will be evaluated. In our study, we aimed to evaluate the effects of Propofol dose according to lean body weight by evaluating patients with bodymass index below 35.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| grup1 Group 1 BMI = 18.5-24.9, |
Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients
It is an observational study and no non-routine procedures will be performed on patients.
Routine anesthesia procedure will be applied to the patients
|
| Group 2 BMI = 25-29.9 BMI = 25-29.9, |
Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients
It is an observational study and no non-routine procedures will be performed on patients.
Routine anesthesia procedure will be applied to the patients
|
| Group 3 BMI=30-34.9 |
Other: It is an observational study and no non-routine procedures will be performed on patients. Routine anesthesia procedure will be applied to the patients
It is an observational study and no non-routine procedures will be performed on patients.
Routine anesthesia procedure will be applied to the patients
|
Outcome Measures
Primary Outcome Measures
- PROPOFOL DOSE [2]
THE RATIO OF PROPOFOL DOSE WITH SUFFICIENT DEPTH OF ANESTHESIA ACCORDING TO TOTAL AND LEATHER BODY WEIGHT
Eligibility Criteria
Criteria
Inclusion Criteria: BMI 18-35 will be included. over 18 years old It will take 2-6 hours Patients who will be operated under general anesthesia will be included.
-
Exclusion Criteria:
PATIENT DOESN'T WANT CONTRAINDICATION OF PROPOFOL Propofol allergy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Inonu universitesi | Malatya | Turkey | 44050 |
Sponsors and Collaborators
- Inonu University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
- Drug dosing in obese adults
- In non-obese patients, duration of action of rocuronium is directly correlated with body mass index.
Publications
- Barras M, Legg A. Drug dosing in obese adults. Aust Prescr. 2017 Oct;40(5):189-193. doi: 10.18773/austprescr.2017.053. Epub 2017 Oct 3. No abstract available.
- Fujimoto M, Tanahira C, Nishi M, Yamamoto T. In non-obese patients, duration of action of rocuronium is directly correlated with body mass index. Can J Anaesth. 2013 Jun;60(6):552-6. doi: 10.1007/s12630-013-9914-x. Epub 2013 Mar 6.
- TOTM