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Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database

Sponsor
Taipei Medical University WanFang Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01280422
Collaborator
(none)
67,128,927
Enrollment
1
Location
5.9
Duration (Months)
11288600.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The doctor's overridden rate for Drug-drug interaction (DDI) alert systems was 85-95% in foreign and there was more than 90% overridden rate in Taiwan. Why DDI alerts systems which spent much time and money to establish could not use medicinal information to increase drug safety? One of the reasons which induced to override was that health care thought there were too much DDI alerts and high false alerts.

The difference between DDI alert systems from pharmacists to confirm drug-drug interaction was that pharmacists not only confirmed ordering drug at the same time but also checked the other drug information such as frequency, rote and refill etc. Therefore, DDI alert systems which were established by drug code alone would induce a lot of false alerts.

In order to study how much false alert rate in drug-drug interactions, this research selected most common drug-drug interaction which was antacids and antibiotics. Antacids were most self-payment so this research needed to analyze ROCDR (Establishing a Multi-Center, Longitudinal, Research-Oriented Clinical Data Repository for Clinical Research). The aim was to study how many drug-drug interactions and false alerts from antacids and antibiotics and analyze the difference in different department. Finally, proposing advice and assessment for building drug-drug interaction alerts system to strength drug information system and increase drug safety.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    67128927 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Retrospective
    Official Title:
    Analysis of Drug-drug Interaction Alert Based on Multicenter Clinical Database
    Study Start Date :
    Feb 1, 2010
    Actual Study Completion Date :
    Aug 1, 2010

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • Select DDI rules: antacids and antibiotics

      • Database: ROCDR (multicenter clinical database)

      • The pharmacists defined six rules which were based on medical knowledge for true alerts or false-alert.

      1. True alert: Rule 1 and Rule 2

      2. "False-alert": Rule 3 or Rule 4

      3. "Other" (Unable to determine): Rule 5 or Rule 6

      Exclusion Criteria:
      • N/A

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Taipei Medical University - WanFang Hospital Taipei Taiwan

      Sponsors and Collaborators

      • Taipei Medical University WanFang Hospital

      Investigators

      • Principal Investigator: Yu-Chuan Li, Taipei Medical University WanFang Hospital

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01280422
      Other Study ID Numbers:
      • 99009
      First Posted:
      Jan 20, 2011
      Last Update Posted:
      Jan 20, 2011
      Last Verified:
      Jan 1, 2011
      Keywords provided by , ,
      ROCDR

      Study Results

      No Results Posted as of Jan 20, 2011