Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma

Sponsor

National Cancer Institute (NCI) (NIH)

Overall Status

Completed

CT.gov ID

NCT00002759

Collaborator

(none)

Enrollment

Location

Arm

Study Details

Study Description

Brief Summary

Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in treating patients who have solid tumors or lymphoma that is refractory to standard therapy. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Cyclosporine and phenobarbital may enhance the effectiveness of irinotecan.

Condition or Disease	Intervention/Treatment	Phase
Drug/Agent Toxicity by Tissue/Organ Lymphoma Neutropenia Small Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific	Drug: cyclosporine Drug: irinotecan hydrochloride Drug: phenobarbital	Phase 1

Detailed Description

OBJECTIVES:

Determine the maximum tolerated dose of irinotecan (CPT-11) when infused weekly with cyclosporine (CYSP) in patients with solid tumors or lymphoma refractory to standard therapy.
Determine whether CYSP modulates the pharmacokinetics and pharmacodynamics of CPT-11 and its active metabolite, SN-38.
Determine whether phenobarbital modulates the pharmacokinetics and pharmacodynamics of CPT-11 and SN-38.

OUTLINE: This is a dose escalation study of irinotecan. Patients are stratified according to gender.

Part I: Patients receive cyclosporine IV over 6 hours and irinotecan IV over 90 minutes weekly for 4 weeks. Courses repeat every 6 weeks in the absence of unacceptable toxicity or disease progression. Cohorts of 3-12 patients receive escalating doses of irinotecan until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which at least one third of patients experience dose limiting toxicity (DLT).

Part IIA: If the DLT is diarrhea in part I, then part IIA is opened. Patients receive oral phenobarbital, cyclosporine as in part I, and irinotecan at the MTD from part I. Dose escalation occurs as in part I to determine a new MTD. If the DLT continues to be diarrhea, the study is closed. Part IIB: If the DLT is neutropenia in part I, then part IIB is opened. Patients receive cyclosporine as in part I and escalating doses of irinotecan to determine a new MTD.

Part III: If the DLT is neutropenia in part IIA or any DLT in part IIB, patients receive phenobarbital, cyclosporine, and irinotecan at the MTD determined as in part IIA or part IIB. Dose escalation continues until a new MTD is determined.

Study Design

Study Type:

Interventional

Actual Enrollment :

3 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A PHASE I STUDY OF IRINOTECAN (CPT-11) WITH PHARMACOKINETIC MODULATION BY CYCLOSPORINE A AND PHENOBARBITAL

Study Start Date :

Jun 1, 1996

Actual Primary Completion Date :

Apr 1, 2002

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm I See detailed description.	Drug: cyclosporine Drug: irinotecan hydrochloride Drug: phenobarbital

Arm

Intervention/Treatment

Experimental: Arm I

See detailed description.

Drug: cyclosporine

Drug: irinotecan hydrochloride

Drug: phenobarbital

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Malignant solid tumor or lymphoma refractory to standard therapy or for which no therapy of proven benefit exists
No leukemia
Measurable or evaluable disease

PATIENT CHARACTERISTICS:

Age: 18 and over
Performance status: Karnofsky 70-100%
Life expectancy: At least 3 months
WBC at least 3,500/mm3
Absolute neutrophil count at least 1,500/mm3
Platelet count at least 100,000/mm3
Hemoglobin at least 9 g/dL
Bilirubin no greater than 1.5 mg/dL
AST/ALT less than twice normal (unless due to disease)
PT and PTT normal
Creatinine no greater than 1.5 mg/dL
Creatinine clearance at least 60 mL/min
No history of congestive heart failure requiring medical therapy
No clinically significant or life threatening cardiac arrhythmia
No history of significant pulmonary disease or lymphangitic lung disease
No hypersensitivity to cyclosporine or cremophore
No history of manifest or latent porphyria or hypersensitivity to barbiturates (for parts of study using phenobarbital)
No history of inflammatory bowel disease requiring therapy
No chronic diarrhea syndrome or paralytic ileus
No medical or psychiatric condition that precludes informed consent
Not pregnant
Effective contraception required of fertile women

PRIOR CONCURRENT THERAPY:

At least 4 weeks since prior biologic therapy
At least 2 weeks since prior colony stimulating factors
At least 4 weeks since prior chemotherapy (at least 6 weeks since nitrosoureas or mitomycin)
No prior bleomycin or irinotecan
At least 4 weeks since prior radiotherapy to greater than 25% of bone marrow
Minimum time interval between prior therapy and eligibility shortened by 2 weeks when phenobarbital is administered
Concurrent use of medications that affect the central nervous or cardiovascular systems (e.g., anticonvulsants, calcium channel blockers, oral contraceptives) must be approved by the Principal Investigator