D&D: Dyslipidemia and Diabetic Retinopathy
The purpose of this study is to determine if the reparative cells of blood vessels called endothelial progenitor cells(EPC) are defective in people with diabetes.
|Condition or Disease||Intervention/Treatment||Phase|
The purpose of this study is to determine if the reparative cells of blood vessels, called endothelial progenitor cells (EPC's) are defective in people with diabetes. Diabetic retinopathy (DR) is an eye disease related to diabetes. It can cause blurred vision and possible bleeding in the blood vessels in the back of the eye (retina). Damage to the cells of the blood vessels from DR can cause vision loss or blindness. Even with current treatments, the quality of life for people with DR is much reduced.
Arms and Interventions
Other: 15 subjects with Non Proliferative Diabetic Retinopathy(mild, moderate and severe). 15 subjects with Proliferative Diabetic Retinopathy
Other: Healthy Controls 15 age matched control subjects
Primary Outcome Measures
- Increase in acid sphingomyelinase (ASM) expression and activity in bone marrow-derived endothelial progenitor cells (EPCs) [3 years]
Peripheral blood of 150 cc, about 8-10 tablespoons will be collected from vein in the arm of both diabetic and control subjects
Any man or woman
Greater than 18 years of age
Diagnosis of diabetes (applies to the Diabetic Arm only) (N=15 Type 1 and N=15 Type
The subject must be willing and have the ability to cooperate with the protocol. Children will not be eligible because the investigators need to obtain 150 ml of blood and this is in excess of what can be drawn in children.
Female participants must not be pregnant at the time of the blood draw as evident through a dipstick pregnancy test.
Have retinal abnormalities other than diabetic retinopathy.
Contacts and Locations
|1||University of Alabama at Birmingham||Birmingham||Alabama||United States||35294|
Sponsors and Collaborators
- University of Alabama at Birmingham
- National Eye Institute (NEI)
- Principal Investigator: Maria B Grant, MD, University of Alabama at Birmingham
Study Documents (Full-Text)None provided.