Early Detection of Lung Cancer In Patients With Chronic Chest Diseases

Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID

Study Details

Study Description

Brief Summary

  • To evaluate the effectiveness of LDCT in detecting early-stage lung cancer in patients with chronic lung conditions compared to standard chest x-rays.

  • To improve lung cancer outcomes through optimized use of radiological technologies for early detection in high-risk patients with pre-existing lung conditions.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The early detection of lung cancer is crucial, as it is one of the most common and deadly types of cancer worldwide. Early detection is especially important in patients with chronic chest diseases, as these underlying conditions can make lung cancer more difficult to diagnose at later stages. Radiological imaging techniques play a key role in the early detection of lung cancer in this high-risk patient population.

    Recent advances in imaging technologies have improved our ability to detect small lung abnormalities indicative of cancer at earlier stages, even before symptoms appear . Techniques such as low-dose CT scanning have been shown to reduce lung cancer mortality by up to 20% compared to chest radiography alone . Advanced imaging allows clinicians to identify subtle nodules or masses in the lungs that may represent cancer .

    Determining the type, size, and extent of lung lesions is important for prognosis and treatment planning . Imaging technologies help characterize lesions as benign or malignant and determine cancer stage . This information guides decisions around surgery, chemotherapy, radiation therapy, or other interventions .

    Early detection through radiological screening has been associated with improved survival rates for lung cancer patients with chronic lung diseases . Screening finds a higher portion of early-stage, potentially curable cancers in this high-risk group . Overall, advanced imaging techniques play a vital role in the early detection and management of lung cancer in patients with underlying chronic chest conditions.

    Study Design

    Study Type:
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Time Perspective:
    Official Title:
    Radiological Early Detection of Lung Cancer In Patients With Chronic Chest Diseases.
    Anticipated Study Start Date :
    Oct 20, 2023
    Anticipated Primary Completion Date :
    Oct 20, 2024
    Anticipated Study Completion Date :
    Dec 20, 2024

    Outcome Measures

    Primary Outcome Measures

    1. Detection early-stage lung cancer (Stage I/II) • Lung • Lung cancer mortality rate [baseline]

      By LDCT

    Secondary Outcome Measures

    1. • Diagnostic accuracy of imaging modalities • Positive predictive value of screening tests • Rate of unnecessary invasive procedures • Identification of high-risk subgroups [baseline]

      BY statiscal anylasis from results

    Eligibility Criteria


    Ages Eligible for Study:
    45 Years to 75 Years
    Sexes Eligible for Study:
    Accepts Healthy Volunteers:
    Inclusion Criteria:

    1- Chronic chest diseases Patients .

    Exclusion Criteria:

    1 - Age: less than 45 years. 2-Patients diagnosed with lung cancer 3-Unstable patients or need for ICU admission

    Contacts and Locations


    No locations specified.

    Sponsors and Collaborators

    • Assiut University


    • Study Chair: Mustafa sayed, lecture, Assiut University

    Study Documents (Full-Text)

    None provided.

    More Information


    Responsible Party:
    Hend Mohamed Sayed Mohamed, Lecture of chest diseases, Assiut University
    ClinicalTrials.gov Identifier:
    Other Study ID Numbers:
    • LDCT &chest diseases
    First Posted:
    Oct 10, 2023
    Last Update Posted:
    Oct 10, 2023
    Last Verified:
    Oct 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    Studies a U.S. FDA-regulated Device Product:

    Study Results

    No Results Posted as of Oct 10, 2023