Early Detection of Prostate Cancer by FACS
Study Details
Study Description
Brief Summary
Early detection of prostrate cancer and development of metastases. The research will attempt to match the SCM test (structuredness of the cytoplasmic matrix) in lymphocytes as an early cancer detection test using Florescent Activated Cell Sorting (FACS) as a replacement for the CellScan instrument. The test is based on measurement of cellular changes in response to the specific prostate antigen, PSA.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| 1 10 diagnosed men in age 60 - 90 with Prostate Cancer |
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| 2 10 patients with benign growth |
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| 3 10 health volunteers |
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| 4 10 patients diagnosed with other cancer |
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
Experimental group : Males between the ages of 60-90 years, with medical diagnosis of prostate cancer according to both clinical and hematological examinations, before receiving any medical treatment.
Control Group 1: Males between the ages of 60-90 years, with diagnosed benign prostate hyperplasia -BPH.
Control Group 2: Males between the ages of 60-90 years, medically diagnosed as healthy.
Control Group 3: Males between the ages of 60-90 years, medically diagnosed with another form of cancer, not prostate.
Exclusion Criteria:
Experimental group: Other known cancer or systemic infection. Control Group 1: Other known cancer or systemic infection. Control Group 2:Past hematological disorders nor cancer growth history. other known systemic infection, nor urinary tract infection. Patients hospitalized for orthopedic injuries of any type who are otherwise free of urinary tract infections.
Control Group 3:Other known systemic infection, nor urinary tract infection.
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Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Urology Department, Ziv Medical Center | Safed | Israel | 20100 |
Sponsors and Collaborators
- Ziv Hospital
Investigators
- Principal Investigator: Nina Kucherski, MD, Ziv Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Altman, Roberta. The prostate Answer Book. Warner Books, lnc., 1993.
- American Cancer Society. National Cnference on Prostate Cancer. Philadelphia, Pennsylvania: September/October 1994.
- Klein O, Lin S, Embon O, Sazbon A, Zidan J, Kook AI. An approach for high sensitivity detection of prostate cancer by analysis of changes in structuredness of the cytoplasmic matrix of lymphocytes specifically induced by PSA-ACT. J Urol. 1999 Jun;161(6):1994-6.
- Rous, Stephen N., M.D.; The prostate Book. W.W. Norton & Co., 1992.
- HP 7-251 S