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The Early Origins of Cardiovascular Disease

Sponsor
Danone Institute International (Other)
Overall Status
Unknown status
CT.gov ID
NCT00923039
Collaborator
(none)
200
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Small body size at birth, slow weight gain during infancy and increase in body mass index after 2 years are independent risk factors for cardiovascular disease and the metabolic syndrome. There is a large gap in our understanding of how early growth affects the cardiovascular system. Possible mechanisms include alterations in body composition, in cardiac structure, in vascular function, in renal function and epigenetic processes.

The Objective is to determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    200 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    The Early Origins of Cardiovascular Disease : the Consequence of Growth Restriction During Foetal Life and Infancy on Cardiovascular Structure and Function in Adulthood
    Study Start Date :
    Jun 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    Exposed/ Not exposed

    Outcome Measures

    Primary Outcome Measures

    1. To determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics [3 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 25 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Male and female volunteers students aged between 18-25 years old

    • Having growth records

    Exclusion Criteria:
    • If young women subject without contraception,or pregnant

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 CIC-UPCET Hopital de la Timone Bat F Marseille France 13385

    Sponsors and Collaborators

    • Danone Institute International

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00923039
    Other Study ID Numbers:
    • NU 304
    First Posted:
    Jun 18, 2009
    Last Update Posted:
    Jun 18, 2009
    Last Verified:
    Jun 1, 2009
    Keywords provided by , ,
    The early origin of cardiovascular disease
    Additional relevant MeSH terms:
    Cardiovascular Diseases

    Study Results

    No Results Posted as of Jun 18, 2009