Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline

• Sponsor: Medical University of Vienna (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT00343122
• Collaborator: (none)
• Enrollment: 100
• Location: 1

Study Details

Study Description

Brief Summary

The purpose of the study is to evaluate agitated saline versus polygeline for detection of intrapulmonary vasodilatation in patients with cirrhosis.

Condition or Disease	Intervention/Treatment	Phase
Liver; Cirrhosis	Procedure: echocardiography for intrapulmonary vasodilatation

Detailed Description

Intrapulmonary vasodilatation is a frequent finding in patients with cirrhosis. Its diagnosis is established via contrast enhanced echocardiography. One used method is the contrast agent agitated saline and another frequently used method is the contrast agent polygeline. The purpose of this study is to compare these two echocardiographic contrast agents with respect to their ability to detect intrapulmonary vasodilatation.

Study Design

• Study Type: Observational
• Anticipated Enrollment: 100 participants
• Observational Model: Defined Population
• Time Perspective: Prospective
• Official Title: Evaluation of Two Methods for the Echocardiographic Assessment of Intrapulmonary Vasodilatation in Patients With Liver Cirrhosis: Agitated Saline Versus Polygelatine
• Study Start Date: Jun 1, 2006

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• age > 18 years

• presence of liver cirrhosis

• evaluation for liver transplantation or transjugular intrahepatic portosystemic shunt

Exclusion Criteria:

• inadequate echocardiographic image quality

• allergies to echocardiographic contrast agents

• pulmonary valve stenosis

• pulmonary embolism

• relevant tricuspid regurgitation

• cardiomyopathy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Intensive Care Unit 13H1, Dep. of Internal Medicine IV, Medical University of Vienna	Vienna		Austria	A-1090

Sponsors and Collaborators

• Medical University of Vienna

Investigators

• Principal Investigator: Peter Schenk, MD, Intensive Care Unit 13h1, Dep. of Internal Medicine IV, Medical University of Vienna

Study Documents (Full-Text)

None provided.

More Information

Publications

• Rodríguez-Roisin R, Krowka MJ, Hervé P, Fallon MB; ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee. Pulmonary-Hepatic vascular Disorders (PHD). Eur Respir J. 2004 Nov;24(5):861-80. Review.

• ClinicalTrials.gov Identifier: NCT00343122
• Other Study ID Numbers: EK 4462005
• First Posted: Jun 22, 2006
• Last Update Posted: Sep 17, 2007
• Last Verified: Sep 1, 2007

• Keywords provided by , ,: liver; cirrhosis; hepatopulmonary syndrome
• Additional relevant MeSH terms: Liver Cirrhosis; Fibrosis

Study Results

No Results Posted as of Sep 17, 2007