Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

Sponsor

Zonguldak Bulent Ecevit University (Other)

Overall Status

Completed

CT.gov ID

NCT05628935

Collaborator

(none)

Enrollment

Location

Actual Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Condition or Disease	Intervention/Treatment	Phase
Inflammation Anesthesia	Procedure: peripheral nerve block

Study Design

Study Type:

Observational

Actual Enrollment :

1 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery

Actual Study Start Date :

Jan 1, 2018

Actual Primary Completion Date :

Nov 1, 2020

Actual Study Completion Date :

Nov 1, 2021

Arms and Interventions

Arm	Intervention/Treatment
Group G Patients Undergoing Forearm Surgery under general anesthesia
Group P Patients Undergoing Forearm Surgery under peripheral nerve block	Procedure: peripheral nerve block local anesthetic application to the brachial plexus

Arm

Intervention/Treatment

Group G

Patients Undergoing Forearm Surgery under general anesthesia

Group P

Patients Undergoing Forearm Surgery under peripheral nerve block

Procedure: peripheral nerve block

local anesthetic application to the brachial plexus

Outcome Measures

Primary Outcome Measures

Neutrophil/lymphocyte ratio [up to 24 hours after surgery]
Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

Secondary Outcome Measures

Platelet/lymphocyte ratio [up to 24 hours after surgery]
Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
Mean Platelet Volume [up to 24 hours after surgery]
Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Underwent forearm surgery
Between aged 18-70
Under general anesthesia or peripheral nerve block

Exclusion Criteria:

acute infection
morbid obesity
chronic treatment with steroids or immunosuppressants
recently received chemotherapy
hepatic and renal dysfunction;
chronic alcohol abusers
Multiple trauma
Patients with missing data in their files

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Zonguldak Bülent Ecevit University Medicine Faculty	Zonguldak	Kozlu	Turkey	67600

Sponsors and Collaborators

Zonguldak Bulent Ecevit University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Bengü Gülhan Köksal, medical doctor, Zonguldak Bulent Ecevit University

ClinicalTrials.gov Identifier:

NCT05628935

Other Study ID Numbers:

2020-22/17

First Posted:

Nov 29, 2022

Last Update Posted:

Nov 29, 2022

Last Verified:

Nov 1, 2022

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Bengü Gülhan Köksal, medical doctor, Zonguldak Bulent Ecevit University

General Anesthesia

Neutrophil Lymphocyte Ratio

Peripheral Nerve Block

Additional relevant MeSH terms:

Inflammation

Study Results

No Results Posted as of Nov 29, 2022