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Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects

Sponsor
Lund University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT00779298
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

Increased intake of dietary fibre and whole grains is related to reduced risk of developing diabetes. The term "whole grain" is often used for whole-meal products in which the structure of the cereal grain is destroyed in the flour containing the original dietary fiber, but also for cereal products in which a large proportion of whole cereal grains is intact. The aim of this study was to evaluate the effect of commercial rye whole-meal bread (RWMB) compared to white-wheat bread (WWB) on gastric emptying rate (GER), postprandial glucose response in healthy subjects.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Ten healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus, were assessed by using a blinded crossover trial. The subjects were examined regarding blood glucose levels and GER after ingestion of 150g WWB or RWMB on two different occasions after an overnight fast. GER was measured using a standardized real time ultrasonography. GER was calculated as a percentage change in antral cross sectional area 15 and 90 minutes after the finished meal with WWB and RWMB. Finger-prick capillary samples were collected before and 40, 60, and 90 min after the start of the meal to measure blood glucose levels.

    Study Design

    Study Type:
    Observational
    Official Title:
    Effect of Commercial Rye Whole-Meal Bread on Postprandial Blood Glucose and Gastric Emptying in Healthy Subjects

    Arms and Interventions

    Arm Intervention/Treatment
    Healthy subjects

    Healthy subjects, without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • without symptoms or a prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus
      Exclusion Criteria:
      • with symptoms or prior history of gastrointestinal disease, abdominal surgery or diabetes mellitus

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Dept. of Medicine, Malmö University Hospital, Malmö Skåne Sweden 205 02

      Sponsors and Collaborators

      • Lund University Hospital

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00779298
      Other Study ID Numbers:
      • Dnr 709/2004
      First Posted:
      Oct 24, 2008
      Last Update Posted:
      Oct 24, 2008
      Last Verified:
      Oct 1, 2008
      Keywords provided by , ,
      rye whole-meal bread
      white-wheat bread
      gastric emptying rate
      postprandial glucose response
      healthy subjects

      Study Results

      No Results Posted as of Oct 24, 2008