Effect of CYP2C9*3 Polymorphism on Ibuprofen in Pakistani Population
Study Details
Study Description
Brief Summary
The goal of this Observational study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were:
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to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen
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to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The goal of this observational study was to identify the effect of CYP2C9*3 gene polymorphism in the Pakistani population, due to the high prevalence of this variant in the Pakistani Population
The main question it aims to answer were:
-
to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen
-
to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.
The blood samples of the participants were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis.
Study Design
Outcome Measures
Primary Outcome Measures
- To evaluate the genetic variabilities in the clinical efficacy of ibuprofen after molar tooth extraction using a visual analog scale VAS [three days]
A Visual Analogue Scale (VAS) is one of the self-administered pain rating scales, to measure pain intensity. The pain was interpreted as no pain (0-4 mm), mild pain(5-44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm).
Secondary Outcome Measures
- To evaluate the genetic variabilities in the tolerability of ibuprofen after molar tooth extraction using the General Assessment of Side Effects GASE scale. [three days]
The self-rating scale General Assessment of Side Effects (GASE), is about the most frequent side effects in clinical trials of different drugs. Every symptom (dyspepsia, nausea, diarrhea) had to be answered twice: first, participants had to rate the intensity of this symptom during the last 3 days, and second, if this symptom was present, participants had to rate whether they attribute it to current drug intake.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Pakistani individuals
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Absence of systemic diseases
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Extractions required based on orthodontic, periodontal, and endodontic indications
Exclusion Criteria:
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history of bleeding or gastrointestinal ulcers
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allergic to ibuprofen or other NSAIDs.
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Pregnancy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ammarah Amjad | Rawalpindi | Punjab | Pakistan | 46000 |
Sponsors and Collaborators
- Riphah International University
Investigators
- Principal Investigator: Ammarah Amjad, BDS, Riphah International University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Riphah/IIMC/IRC/22/2072