Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
Study Details
Study Description
Brief Summary
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
Detailed Description
When a patient presents to the Maternal Hypertension Center at Cabell Huntington Hospital, she will receive a non-invasive hemodynamic assessment via the NICaS system as per usual protocol. The NICaS system uses impedance cardiography which provides a reliable assessment of cardiovascular, respiratory, and fluid parameters. In typical practice, the vasodilator nifedipine is initiated for increased systemic vascular resistance and elevated cardiac output is treated with beta blockade (via either atenolol or labetalol). The medication to be given to each subject will be based on their hemodynamics. Specifically, nifedipine will be given for a mean arterial pressure >100 and a beta blocker will be given for a cardiac output
8 l/min. The patients will be asked to return in one week for repeat ICG measurement.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Beta blockade Beta blocker (labetalol or atenolol) will be given for a cardiac output >8 l/min. |
Drug: Labetalol
Beta blocker
Other Names:
Drug: Atenolol
Beta blocker
Other Names:
|
| Nifedipine Nifedipine will be given for a mean arterial pressure >100. |
Drug: Nifedipine
Calcium channel blocker
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Systolic blood pressure [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured in mmHg
- Diastolic blood pressure [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured in mmHg
- Mean arterial pressure [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured in mmHg
- Heart rate [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured in beats per minute
- Cardiac output [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured in liters per minute
- Systemic vascular resistance [Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.]
Measured by dynes ยท sec/cm^-5
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital
-
English speaking
-
18-45 years old.
-
Willing to provide informed consent
-
Gestational age prior to 15 weeks gestation
Exclusion Criteria:
-
Non-English speaking patients, patients
-
<18 years old or >45 years old
-
Not willing or able to provide consent
-
Gestational age >15 weeks
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Maternal Hypertension Center at Cabell Huntington Hospital | Huntington | West Virginia | United States | 25701 |
Sponsors and Collaborators
- Marshall University
Investigators
- Principal Investigator: Jesse Cottrell, MD, Marshall University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1681431