Clincosm LogoSign in Get a demo

Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE (OSAS)

Sponsor
Erzurum Regional Training & Research Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01635699
Collaborator
(none)
49
Enrollment
1
Location
33
Duration (Months)
1.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine the possible effects of uvulopalatopharngoplasty (UPPP) -which is a a therapy used on patients with Obstructive sleep apnea syndrome (OSAS- on oxidative damage.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Obstructive sleep apnea syndrome (OSAS) is a sydrome which has characteristic upper way obstruction and a decrease in blood oxygen saturation as sleeping. uvulopalatopharngoplasty (UPPP)is one of the surgical approaches applied to the patients with OSAS, since the oxidative damage markers have been found high in patients with OSAS. Although antioxidant levels were higher in patients with OSAS than those in normal population, there is report about the effect of UPPP on antioxidant status in patients with OSAS. We performed this study to confirm whether is there a We performed the present study to confirm whether there is a relationship between the OSAS and oxidative damage before and after UPPP.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    49 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE
    Study Start Date :
    Jun 1, 2008
    Actual Primary Completion Date :
    Jun 1, 2008
    Actual Study Completion Date :
    Mar 1, 2011

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • Patients who underwent uvulopalatopharngoplasty (UPPP)for Obstructive sleep apnea syndrome (OSAS)
      Exclusion Criteria:
      • Anormal nasopharyngeal computed tomography, chronic diseases such as diabetes mellitus, hypertension etc.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Erzurum Regional Educational Researh Hospital Erzurum Turkey 25000

      Sponsors and Collaborators

      • Erzurum Regional Training & Research Hospital

      Investigators

      • Principal Investigator: vural fidan, operating surgeon doctor, eskisehir yunus emre state hospital (still works here)

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Vural Fidan, operating surgeon doctor, Erzurum Regional Training & Research Hospital
      ClinicalTrials.gov Identifier:
      NCT01635699
      Other Study ID Numbers:
      • ATUNI-1
      First Posted:
      Jul 9, 2012
      Last Update Posted:
      Jul 9, 2012
      Last Verified:
      Jul 1, 2012
      Keywords provided by Vural Fidan, operating surgeon doctor, Erzurum Regional Training & Research Hospital
      DNA oxidation
      obstructive sleep apnea
      lipid peroxidation
      oxidative stresses
      Additional relevant MeSH terms:
      Apnea
      Sleep Apnea Syndromes
      Sleep Apnea, Obstructive

      Study Results

      No Results Posted as of Jul 9, 2012