Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

• Sponsor: Future University in Egypt (Other)
• Overall Status: Completed
• CT.gov ID: NCT05295576
• Collaborator: (none)
• Enrollment: 50
• Location: 1
• Actual Duration (Months): 9.1
• Patients Per Site Per Month: 5.5

Study Details

Study Description

Brief Summary

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Condition or Disease	Intervention/Treatment	Phase
Aggressive Periodontitis	Procedure: non surgical periodontal therapy

Detailed Description

Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.

Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

Study Design

• Study Type: Observational
• Actual Enrollment: 50 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Official Title: Effect of Non Surgical Periodontal Therapy on Levels of Il-17 and Il-18 in Chronic Periodontitis Patients Versus Periodontally Healthy Individuals
• Actual Study Start Date: Mar 27, 2021
• Actual Primary Completion Date: Dec 15, 2021
• Actual Study Completion Date: Dec 30, 2021

Arms and Interventions

Arm	Intervention/Treatment
chronic periodontitis scaling and root planing	Procedure: non surgical periodontal therapy; Scaling and root planing
Periodontally healthy individuals no treatment

Outcome Measures

Primary Outcome Measures

1. measure levels of Il-17 and Il-18 in chronic periodontitis patients [Change from Baseline Il-17 andIl-18 at 3 months]

   measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients

Eligibility Criteria

Criteria

• Ages Eligible for Study: 30 Years to 60 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Medically free subjects .

• both genders .

• age range between 30 to 60 years old .

Exclusion Criteria:

• Subjects with periodontal surgeries in the last 6 months.

• Subjects with prior use of antibiotics in the last 6 months.

• Smokers.

• Pregnant and lactating females were excluded.

• Lactating females.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Future university in Egypt	Cairo		Egypt	11835

Sponsors and Collaborators

• Future University in Egypt

Investigators

• Principal Investigator: Sarah M Elkot, Lecturer, Lecturer of Oral Medicine and Periodontology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Sarah Elkot, Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt., Future University in Egypt
• ClinicalTrials.gov Identifier: NCT05295576
• Other Study ID Numbers: FUE12
• First Posted: Mar 25, 2022
• Last Update Posted: Mar 25, 2022
• Last Verified: Mar 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Undecided
• Plan to Share IPD: Undecided
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Periodontitis; Chronic Periodontitis; Aggressive Periodontitis

Study Results

No Results Posted as of Mar 25, 2022