The Effect of Obesity in COPD Mechanically Ventilated Patients

Sponsor

Assiut University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06048549

Collaborator

(none)

200

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Study the relationship between the body mass index and duration of mechanical ventilation & complications in mechanically ventilated COPD patients.

Study the effect of obesity on mortality rate of COPD mechanically ventilated patients.

Determine prevalence of obesity in mechanically ventilated COPD patients.

Condition or Disease	Intervention/Treatment	Phase
Effects of Obesity on COPD Mechanically Ventilated Patients

Detailed Description

Obesity has become a global epidemic with prevalence rising both in developed and developing countries. The percentage of patients with obesity in the intensive care unit (ICU) can be expected to increase concomitantly or even more since obesity increases the risk for a more severe disease course with more need for ICU admission and mechanical ventilation .

Obesity, especially abdominal obesity (android fat distribution) and severe obesity, results in altered respiratory anatomy and physiology and, therefore, complicated airway management and adapted ventilator settings during mechanical ventilation. Obesity appears to be associated with an increased risk of acute respiratory distress syndrome (ARDS) and infection, mainly pneumonia probably related to an imbalanced production of adipokines. In ventilated patients, obesity increases ICU length of stay and the duration of mechanical ventilation .

Obesity is relatively common among individuals with COPD, corresponding to 20%-35% of patients with COPD. Increasing evidence suggests that obesity is a risk factor for impaired quality of life, exercise intolerance, and suboptimal disease control in COPD .

Study Design

Study Type:

Observational

Anticipated Enrollment :

200 participants

Observational Model:

Other

Time Perspective:

Prospective

Official Title:

Effect Of Obesity on The Outcome Of Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Anticipated Study Start Date :

Oct 1, 2023

Anticipated Primary Completion Date :

Oct 1, 2024

Anticipated Study Completion Date :

Dec 1, 2024

Outcome Measures

Primary Outcome Measures

Study the effect of obesity on morbidity and mortality rate of COPD mechanically ventilated patients. [one year]
Study the relationship between the body mass index and duration of mechanical ventilation & complications in mechanically ventilated COPD patients.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Adult patients of both genders more than 18 years old admitted at RICU, diagnosed COPD and need mechanical ventilation from August 2023 to August 2024.

Exclusion Criteria:

patients less than 18 years old. patients who refused to participate in the research. patients with missing data.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Assiut University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Asmaa Gamal Abd Elhamied, Assistant lecturer at Assiut university hospital, Assiut University

ClinicalTrials.gov Identifier:

NCT06048549

Other Study ID Numbers:

Obesity COPD Patients

First Posted:

Sep 21, 2023

Last Update Posted:

Sep 21, 2023

Last Verified:

Sep 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Obesity

Study Results

No Results Posted as of Sep 21, 2023