Effect of Rocuronium on BIS Values
Study Details
Study Description
Brief Summary
Aim of this trial is to define if Trend of Four (TOF) values after a bolus of rocuronium is correlated with Bispectral Index BIS values during standard general anaesthesia for breast surgery.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
Detailed Description
Rocuronium. a curarizing agent, has been shown to decrease Bispectral Index (BIS) in awake volunteers.
However, correlation between Trend of Four (TOF) values after a bolus of rocuronium and BIS values during general anaesthesia for breast surgery has not been defined yet.
Investigators want to analyze this correlation during general anaesthesia conducted using Propofol and remifentanil. All of these drugs will be delivered with Targeted-Controlled Infusion pumps (in particular Eleveld for Propofol, Minto for Remifentanil), commonly used to deliver general anaesthesia. At stable anaesthesia maintenance, if requested for surgical (ie more muscle relaxation) or anesthesiological reasons (i.e. avoid air insufflation) a standard Rocuronium bolus (0.6 mg/kg) was given. In these case, with rocuronium bolus justified by clinical reasons, authors will observationally record the BIS values and the TOF values.
Study Design
Outcome Measures
Primary Outcome Measures
- Correlation between Trend of Four (TOF) and Bispectral Index (BIS) values [60 minutes after rocuronium bolus]
Discover if there is linear correlation between TOF values (utilized for curarization monitoring) and BIS values (utilized for deep of hypnosis monitoring) during standard general anaesthesia conducted with Propofol and remifentanil with targeted controlled infusion pumps, usually adopted in our Hospital to delivery general anaesthesia
Eligibility Criteria
Criteria
Inclusion Criteria:
- Undergo General Anaesthesia with Propofol and Remifentanil, and necessity of curarization with Rocuronium for surgical or ventilatory reasons.
Exclusion Criteria:
-
Neurological disease
-
Psychiatric disease
-
Benzodiazepines praemedication
-
Obesity
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Padova
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RocuMAST