The Effect of Trendelenburg Position on CCA Blood Flow

Sponsor

Seoul National University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT04233177

Collaborator

(none)

Enrollment

Location

13.4

Actual Duration (Months)

1.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.

Condition or Disease	Intervention/Treatment	Phase
Perfusion Perioperative/Postoperative Complications

Detailed Description

The study will include 20 patients undergoing gynecological surgery. The common carotid artery blood flow will be measured using Doppler US during the following conditions; supine position before induction of anesthesia, supine position immediately after induction of anesthesia, supine position with penumoperitoneum, head-down position with or without pneumoperitoneum.

Study Design

Study Type:

Observational

Actual Enrollment :

20 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Influence of Anesthesia, Pneumoperitoneum, and Patient Position on Common Carotid Artery Blood Flow During Laparoscopic Gynecology Operation

Actual Study Start Date :

Jan 13, 2020

Actual Primary Completion Date :

Feb 23, 2021

Actual Study Completion Date :

Feb 23, 2021

Outcome Measures

Primary Outcome Measures

Change of the common carotid artery blood flow velocity [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Common carotid artery blood flow velocity is measured using Doppler US

Secondary Outcome Measures

Change of the common carotid artery beat volume [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Common carotid artery beat volume was calculated from median common carotid artery beat velocity and vessel diameter
Change of the common carotid artery diameter [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Common carotid artery diameter is obtained using US
Change of mean arterial blood pressure [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Mean arterial pressure is obtained concurrently with common carotid artery blood flow velocity measurements
Change of cardiac output [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Cardiac output was obtained using FloTrac(EdwardLifescience, USA)
Change of peak inspiration airway pressure [1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position]
Peak inspiratory airway pressure is obtained using the ventilator system

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

ASA class I,II
patients undergoing gynecology surgery under trendelenburg position
Age ranges from 20 to 70

Exclusion Criteria:

BMI > 32
Pregnancy
Patients who did not agree to study
Patients with allergies to the drugs used in this study
Patients with anatomical variations or lesions in cervical or cranial vascular portion
Patients with arrhythmia that may alter patient's cardiac output(e.g. artrial fibrillation)