Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis

Sponsor

Tanta University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT06006663

Collaborator

(none)

Enrollment

Arms

3.5

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Condition or Disease	Intervention/Treatment	Phase
Effective Intracanal Medicaments Against Enterococcus Faecalis	Drug: Ibuprofen 400 mg. Drug: modified triple antibiotic paste Dietary Supplement: curcumin Dietary Supplement: olive leaves extract	Phase 2/Phase 3

Detailed Description

we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .

samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.

bacterial reduction will be determined and comparision will be made .

Study Design

Study Type:

Interventional

Anticipated Enrollment :

32 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Single (Participant)

Primary Purpose:

Treatment

Official Title:

Antimicrobial Efficacy of Synthetic Versus Herbal Intracanal Medicaments Against Enterococcus Faecalis

Anticipated Study Start Date :

Aug 26, 2023

Anticipated Primary Completion Date :

Oct 5, 2023

Anticipated Study Completion Date :

Dec 10, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: group 1 ibuprofen as intracanal medicament	Drug: Ibuprofen 400 mg. synthetic intracanal medicament
Active Comparator: group 2 modified triple antibiotic paste as intracanal medicament	Drug: modified triple antibiotic paste synthetic intracanal medicament Other Names: clindamycin, ciprofloxacin and metronidazole
Active Comparator: group 3 curcumin as intracanal medicament	Dietary Supplement: curcumin herbal intracanal medicament
Active Comparator: group 4 olive leaves as intracanal medicament	Dietary Supplement: olive leaves extract herbal intracanal medicament

Outcome Measures

Primary Outcome Measures

measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments [time necessary for incubation of each sample is 24 hour]
sample 1 will be taken after gutta percha removal sample 2 will be taken after cleaning and shaping sample 3 will be taken after apllying the intracanal medicament for one week

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Single rooted teeth.
Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.