Elastography and Treatment of Lymphoma
Study Details
Study Description
Brief Summary
To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma.
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Detailed Description
Lymphomas are a heterogeneous group of malignancies that arise from the clonal proliferation of lymphocytes. It represents approximately 5% of malignancies. Overall survival is estimated to be 72%. (1)
Lymphomas are broadly classified into Hodgkin lymphoma (HL) (10%) and Non-Hodgkin lymphoma (NHL) (90%).
HL is further classified into classical and non-classical types and NHL into B-cell, T-cell and natural killer (NK) cell types. Diagnosis of lymphoma is confirmed by histopathology (FNAC, True-cut or excisional biopsy).(2) The standard treatment of lymphoma is chemotherapy and radiotherapy.
The modalities used for staging and follow up of lymphoma are:
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Computed Tomography (CT) chest, abdomen and pelvis.
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Positron Emission Tomography (PET/CT).
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Whole body Magnetic Resonance Imaging (MRI).(3)
Sonoelastography is a new technique that depends on the elastic properties of soft tissues, with the idea of malignant lesions being stiffer than benign or normal tissue. It may have a dependable role in evaluation of therapeutic response in patients with lymphoma and can be used for follow up, the same way it has been used in different parts of the body, such as the breast, and thyroid. To the best of our knowledge, there are few studies concerning the role of elastography in the field of lymphoma disease.(4)
Study Design
Outcome Measures
Primary Outcome Measures
- To determine accuracy of elastography in assessment of superficial lymph nodes response to treatment in cases of lymphoma. [Average three years]
Sonoelastography is a new technique that depends on the elastic properties of soft tissues, with the idea of malignant lesions being stiffer than benign or normal tissue. It may have a dependable role in evaluation of therapeutic response in patients with lymphoma and can be used for follow up, the same way it has been used in different parts of the body, such as the breast, and thyroid. To the best of our knowledge, there are few studies concerning the role of elastography in the field of lymphoma disease.
Eligibility Criteria
Criteria
Inclusion Criteria:
- patients who are histopathologically proven as lymphoma, not receive treatment and have superficial lymphadenopathy.
Exclusion Criteria:
- 1-Lymphoma without superficial lymph nodes. 2-patients under treatment.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Principal Investigator: Kerols Refaat, Resident, Assiut University
- Study Director: Nagham Nabil, Professor, Assiut University
- Study Director: Abdel-Monem Sayed, Lecture, Assiut University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Elastography and lymphoma