Elastography in Thyroid Nodules
Study Details
Study Description
Brief Summary
Nodular goiter is a highly prevalent disease in iodine-deficient areas. Usually nodule assessment includes ultrasonography (US) and fine-needle aspiration (FNA), but some benign nodules can hardly be distinguished from carcinomas. Elastography measures tissue elasticity using sonography, as malignancy is related to stiffness of solid organs. The investigators have designed a study to evaluate the diagnostic accuracy of elastography in nodular goiter. Consecutive patients will be assessed using US, FNA and elastography; the latter will be compared with cytology. Specificity, sensitivity, and predictive values will be calculated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Aims:
Primary aim: to evaluate the diagnostic accuracy of elastography in thyroid nodules from a low-risk of thyroid cancer population.
Secondary aim: to evaluate the usefulness of elastography to detect carcinomas in thyroid nodules with indeterminate FNA.
Patient selection:
Inclusion criteria:
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Age > 18 yr.
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Recruitment in Endocrinology Clinics.
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Nodular goiter.
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Multinodular goiter with dominant nodule > 1 cm.
Exclusion criteria:
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Toxic nodules
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Non-accessible nodules to US or FNA
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Cystic nodules
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Nodules with calcifications in egg rind
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Contraindication for FNA
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Goiter Patients with nodular goiter |
Device: Elastography
Performance of US, elastography and FNA.
|
Outcome Measures
Primary Outcome Measures
- Diagnostic accuracy of elastography for thyroid cancer [1 day]
Sensitivity, specifity, predictive values
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age > 18 yr.
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Recruitment in Endocrinology surgery.
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Nodular goiter.
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Multinodular goiter with dominant nodule > 1 cm.
Exclusion Criteria:
-
Toxic nodules
-
Non-accessible nodules to US or FNA
-
Cystic nodules
-
Nodules with calcifications in egg rind
-
Contraindication of FNA
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Complejo Asistencial de León | León | Spain | 24008 |
Sponsors and Collaborators
- Castilla-León Health Service
Investigators
- Principal Investigator: Alfonso Vidal-Casariego, MD, Complejo Asistencial de León
Study Documents (Full-Text)
None provided.More Information
Publications
- Dighe M, Kim J, Luo S, Kim Y. Utility of the ultrasound elastographic systolic thyroid stiffness index in reducing fine-needle aspirations. J Ultrasound Med. 2010 Apr;29(4):565-74.
- Friedrich-Rust M, Sperber A, Holzer K, Diener J, Grünwald F, Badenhoop K, Weber S, Kriener S, Herrmann E, Bechstein WO, Zeuzem S, Bojunga J. Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules. Exp Clin Endocrinol Diabetes. 2010 Oct;118(9):602-9. doi: 10.1055/s-0029-1237701. Epub 2009 Oct 23.
- Luo S, Kim EH, Dighe M, Kim Y. Screening of thyroid nodules by ultrasound elastography using diastolic strain variation. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4420-3. doi: 10.1109/IEMBS.2009.5332744.
- Tonacchera M, Pinchera A, Vitti P. Assessment of nodular goitre. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):51-61. doi: 10.1016/j.beem.2009.08.008. Review.
- TNUS122009