WMLTM: Electrophysiological Signatures of Distinct Working Memory Subprocesses That Predict Long-term Memory Success

• Sponsor: University of Chicago (Other)
• Overall Status: Enrolling by invitation
• CT.gov ID: NCT05892419
• Collaborator: (none)
• Enrollment: 96
• Location: 1
• Anticipated Duration (Months): 49
• Patients Per Site Per Month: 2

Study Details

Study Description

Brief Summary

Healthy young adults will view pictures of items while the investigators record electroencephalogram (EEG) brain activity. Then, the investigators will ask the participants to report which items the participants remember seeing. The investigators will examine how the measured brain activity relates to which pictures the participants remember.

Condition or Disease	Intervention/Treatment	Phase
Memory; EEG	Other: No intervention

Detailed Description

Electrophysiological signatures track distinct subprocesses of working memory, including the number of items and the spatial locations of those items. By identifying how these subprocesses predict long-term memory success in healthy young adults, this project should lead to an intricate understanding of the relationship between working memory and long-term memory. This study will investigate when and how long-term memory failures arise, by using sophisticated machine learning analyses of neural data. Moreover, this study will test the extent to which the investigators can track working memory processes in real time and how the investigators can leverage that information to improve long-term memory success. This will inform basic theories of the relationship between working memory and long-term memory and motivate future applications.

Study Design

• Study Type: Observational
• Anticipated Enrollment: 96 participants
• Observational Model: Other
• Time Perspective: Other
• Official Title: Electrophysiological Signatures of Distinct Working Memory Subprocesses That Predict Long-term Memory Success
• Actual Study Start Date: Jul 1, 2022
• Anticipated Primary Completion Date: Jul 31, 2024
• Anticipated Study Completion Date: Jul 31, 2026

Outcome Measures

Primary Outcome Measures

1. Memory performance [This task is performed multiple time within the experimental session, which in total lasts around 3 hours.]

   To measure recognition memory performance, participants will view pictures and respond as to whether they remember previously seeing these items. Participants will be shown both old and new items. In the long-term memory phase, they will report their confidence at having seen each image using a four point rating scale, ranging from being confident the item is new (i.e., not previously seen) to being confident the item is old (i.e., previously seen).

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 35 Years
• Sexes Eligible for Study: All

Inclusion Criteria:

• normal or corrected to normal vision

Exclusion Criteria:

• non-fluent in English

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Chicago	Chicago	Illinois	United States	60637

Sponsors and Collaborators

• University of Chicago

Investigators

• Principal Investigator: Megan deBettencourt, University of Chicago
• Principal Investigator: Ed Vogel, University of Chicago
• Principal Investigator: Ed Awh, University of Chicago

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Chicago
• ClinicalTrials.gov Identifier: NCT05892419
• Other Study ID Numbers: IRB15-1290
• First Posted: Jun 7, 2023
• Last Update Posted: Jun 9, 2023
• Last Verified: Jun 1, 2023

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Study Results

No Results Posted as of Jun 9, 2023