ENDO-MRI: ENDOMETRIOSIS - MRI
Study Details
Study Description
Brief Summary
Endometriosis is a frequent pathology with an estimated prevalence of 10% of women of childbearing age. There is no exact correspondence between the symptoms described by the patients and the severity of the lesions, which makes clinical diagnosis difficult. It therefore seems important to improve the complementary examinations available to make the diagnosis more precise and to better study the effectiveness of the treatments implemented. The clinical examination and per-surgical findings of patients with deep pelvic endometriosis show a clear decrease in the mobility of the pelvic organs in relation to each other, but few studies have looked at this mobility, which could however have an implication in explaining the pathophysiology of the disease and the symptomatology of the patients, as well as in the detection of lesions preoperatively. The persistence of hypo-mobility could also help to understand treatment failures.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| patients with pelvic endometriosis Patients referred for suspected pelvic endometriosis, with pelvic endometriosis on initial MRI |
Other: Dynamic MRI Sequence
Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care
|
| patients without pelvic endometriosis Patients referred for suspected pelvic endometriosis but without endometriosis found on diagnostic MRI. |
Other: Dynamic MRI Sequence
Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care
|
Outcome Measures
Primary Outcome Measures
- the mean vertical displacement (in millimeters) measured on the anterior wall of the vagina between rest and maximum pushing force during dynamic MRI [Baseline]
Secondary Outcome Measures
- the mean vertical displacement (in millimetres) measured on the cervix between rest and maximum thrust effort during dynamic MRI. [Baseline]
- the mean vertical displacement (in millimetres) measured on the posterior wall of the vagina between rest and maximum pushing force during dynamic MRI. [Baseline]
- the measurement of variation in mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort between the initial dynamic MRI of patients with [Baseline]
- the statistical association between the symptoms of patients with endometriosis and the mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort during dynamic MRI. [Baseline]
Initial symptoms are associated with initial dynamic MRI data and post therapeutic symptoms are associated with post-therapeutic dynamic MRI data. The symptoms of interest are dysmenorrhea, non-cyclic pelvic pain, dysuria, dychesia, transit disorders (diarrhea/constipation), and dyspareunia.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patient referred for suspected pelvic endometriosis requiring pelvic MRI
-
Female, nulliparous,
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patient with signed written consent, patient with health insurance,
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patient willing to comply with all study procedures and duration
Exclusion Criteria:
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BMI > 35,
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history of hereditary collagen and elastic tissue disease,
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history of pelviperitonitis,
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history of major pelvic surgery,
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inability to receive informed information,
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inability to participate in the entire study,
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lack of social security coverage,
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refusal to sign consent
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University Hospital, Lille
Investigators
- Principal Investigator: Chrystele RUBOD, MD,PhD, University Hospital, Lille
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022_0032
- 2022-A02135-38